Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens

Cordula A Jilg; Vanessa Drendel; Janina Bacher; Przemyslaw Pisarski; Hannes Neeff; Oliver Drognitz; Malte Schwardt; Sven Gläsker; Angelica Malinoc; Zoran Erlic; Mercedes Nunez; Alexander Weber; Pablo Azurmendi; Wolfgang Schultze-Seemann; Martin Werner; Hartmut P H Neumann

doi:10.1159/000351049

Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens

Cordula A Jilg, Vanessa Drendel, Janina Bacher, Przemyslaw Pisarski, Hannes Neeff, Oliver Drognitz, Malte Schwardt, Sven Gläsker, Angelica Malinoc, Zoran Erlic, Mercedes Nunez, Alexander Weber, Pablo Azurmendi, Wolfgang Schultze-Seemann, Martin Werner, Hartmut P H Neumann

Neurochirurgie

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BACKGROUND: The role of autosomal dominant polycystic kidney disease (ADPKD) as a risk factor for renal cell carcinoma (RCC) is still under discussion. Data on prevalence of RCC in ADPKD are limited, especially on a large population scale. The aim of this study was to analyze the prevalence of RCC in ADPKD kidneys and characterize the clinical features of this coincidence.

METHODS: Based on our histopathological registry for ADPKD and the Else Kröner-Fresenius Registry, we retrospectively reviewed malignant and benign renal lesions in patients with ADPKD who had undergone renal surgery from 1988 to 2011.

RESULTS: 240 ADPKD patients underwent 301 renal surgeries. Mean age at surgery was 54 years. Overall, 16 malignant and 11 benign lesions were analyzed in 301 kidneys (5.3%; 3.7%), meaning that 12/240 (5%; 1:20) patients presented with malignant renal lesions. 66.7% (8/12) of these patients had undergone dialysis prior to surgery. We found 10/16 (63%) papillary RCC, 5/16 (31%) clear cell RCC, and 1/16 (6%) papillary noninvasive urothelial cancer. Regarding all renal lesions, 6/17 (35.3%) patients had more than one histological finding in their kidneys. In 2 cases, metachronous metastases were removed. Mean follow-up was 66.7 months.

CONCLUSION: Kidney-related prevalence of RCC in ADPKD kidneys was surprisingly high. Whether or not this is due to chronic dialysis or due to the underlying disease is still speculative. Like other cystic renal diseases with an increased risk for RCC, the attending physician should be aware of the malignant potential of ADPKD, especially with concomitant dialysis.

Originele taal-2	English
Pagina's (van-tot)	13-21
Aantal pagina's	9
Tijdschrift	Nephron Clinical Practice
Volume	123
Nummer van het tijdschrift	1-2
DOI's	https://doi.org/10.1159/000351049
Status	Published - 2013

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10.1159/000351049

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Jilg, C. A., Drendel, V., Bacher, J., Pisarski, P., Neeff, H., Drognitz, O., Schwardt, M., Gläsker, S., Malinoc, A., Erlic, Z., Nunez, M., Weber, A., Azurmendi, P., Schultze-Seemann, W., Werner, M., & Neumann, H. P. H. (2013). Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens. Nephron Clinical Practice, 123(1-2), 13-21. https://doi.org/10.1159/000351049

Jilg, Cordula A ; Drendel, Vanessa ; Bacher, Janina ; Pisarski, Przemyslaw ; Neeff, Hannes ; Drognitz, Oliver ; Schwardt, Malte ; Gläsker, Sven ; Malinoc, Angelica ; Erlic, Zoran ; Nunez, Mercedes ; Weber, Alexander ; Azurmendi, Pablo ; Schultze-Seemann, Wolfgang ; Werner, Martin ; Neumann, Hartmut P H. / Autosomal dominant polycystic kidney disease : prevalence of renal neoplasias in surgical kidney specimens. In: Nephron Clinical Practice. 2013 ; Vol. 123, Nr. 1-2. blz. 13-21.

@article{791a92fe98e848079a838eb1e195e49a,

title = "Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens",

abstract = "BACKGROUND: The role of autosomal dominant polycystic kidney disease (ADPKD) as a risk factor for renal cell carcinoma (RCC) is still under discussion. Data on prevalence of RCC in ADPKD are limited, especially on a large population scale. The aim of this study was to analyze the prevalence of RCC in ADPKD kidneys and characterize the clinical features of this coincidence.METHODS: Based on our histopathological registry for ADPKD and the Else Kr{\"o}ner-Fresenius Registry, we retrospectively reviewed malignant and benign renal lesions in patients with ADPKD who had undergone renal surgery from 1988 to 2011.RESULTS: 240 ADPKD patients underwent 301 renal surgeries. Mean age at surgery was 54 years. Overall, 16 malignant and 11 benign lesions were analyzed in 301 kidneys (5.3%; 3.7%), meaning that 12/240 (5%; 1:20) patients presented with malignant renal lesions. 66.7% (8/12) of these patients had undergone dialysis prior to surgery. We found 10/16 (63%) papillary RCC, 5/16 (31%) clear cell RCC, and 1/16 (6%) papillary noninvasive urothelial cancer. Regarding all renal lesions, 6/17 (35.3%) patients had more than one histological finding in their kidneys. In 2 cases, metachronous metastases were removed. Mean follow-up was 66.7 months.CONCLUSION: Kidney-related prevalence of RCC in ADPKD kidneys was surprisingly high. Whether or not this is due to chronic dialysis or due to the underlying disease is still speculative. Like other cystic renal diseases with an increased risk for RCC, the attending physician should be aware of the malignant potential of ADPKD, especially with concomitant dialysis.",

keywords = "Carcinoma, Renal Cell, Comorbidity, Female, Germany, Humans, Kidney Neoplasms, Male, Middle Aged, Polycystic Kidney, Autosomal Dominant, Prevalence, Renal Dialysis, Risk Assessment, Journal Article",

author = "Jilg, {Cordula A} and Vanessa Drendel and Janina Bacher and Przemyslaw Pisarski and Hannes Neeff and Oliver Drognitz and Malte Schwardt and Sven Gl{\"a}sker and Angelica Malinoc and Zoran Erlic and Mercedes Nunez and Alexander Weber and Pablo Azurmendi and Wolfgang Schultze-Seemann and Martin Werner and Neumann, {Hartmut P H}",

note = "Copyright {\textcopyright} 2013 S. Karger AG, Basel.",

year = "2013",

doi = "10.1159/000351049",

language = "English",

volume = "123",

pages = "13--21",

journal = "Nephron Clinical Practice",

issn = "1660-2110",

publisher = "S. Karger AG",

number = "1-2",

}

Jilg, CA, Drendel, V, Bacher, J, Pisarski, P, Neeff, H, Drognitz, O, Schwardt, M, Gläsker, S, Malinoc, A, Erlic, Z, Nunez, M, Weber, A, Azurmendi, P, Schultze-Seemann, W, Werner, M & Neumann, HPH 2013, 'Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens', Nephron Clinical Practice, vol. 123, nr. 1-2, blz. 13-21. https://doi.org/10.1159/000351049

Autosomal dominant polycystic kidney disease : prevalence of renal neoplasias in surgical kidney specimens. / Jilg, Cordula A; Drendel, Vanessa; Bacher, Janina; Pisarski, Przemyslaw; Neeff, Hannes; Drognitz, Oliver; Schwardt, Malte; Gläsker, Sven; Malinoc, Angelica; Erlic, Zoran; Nunez, Mercedes; Weber, Alexander; Azurmendi, Pablo; Schultze-Seemann, Wolfgang; Werner, Martin; Neumann, Hartmut P H.

In: Nephron Clinical Practice, Vol. 123, Nr. 1-2, 2013, blz. 13-21.

Onderzoeksoutput: Article › peer review

TY - JOUR

T1 - Autosomal dominant polycystic kidney disease

T2 - prevalence of renal neoplasias in surgical kidney specimens

AU - Jilg, Cordula A

AU - Drendel, Vanessa

AU - Bacher, Janina

AU - Pisarski, Przemyslaw

AU - Neeff, Hannes

AU - Drognitz, Oliver

AU - Schwardt, Malte

AU - Gläsker, Sven

AU - Malinoc, Angelica

AU - Erlic, Zoran

AU - Nunez, Mercedes

AU - Weber, Alexander

AU - Azurmendi, Pablo

AU - Schultze-Seemann, Wolfgang

AU - Werner, Martin

AU - Neumann, Hartmut P H

PY - 2013

Y1 - 2013

N2 - BACKGROUND: The role of autosomal dominant polycystic kidney disease (ADPKD) as a risk factor for renal cell carcinoma (RCC) is still under discussion. Data on prevalence of RCC in ADPKD are limited, especially on a large population scale. The aim of this study was to analyze the prevalence of RCC in ADPKD kidneys and characterize the clinical features of this coincidence.METHODS: Based on our histopathological registry for ADPKD and the Else Kröner-Fresenius Registry, we retrospectively reviewed malignant and benign renal lesions in patients with ADPKD who had undergone renal surgery from 1988 to 2011.RESULTS: 240 ADPKD patients underwent 301 renal surgeries. Mean age at surgery was 54 years. Overall, 16 malignant and 11 benign lesions were analyzed in 301 kidneys (5.3%; 3.7%), meaning that 12/240 (5%; 1:20) patients presented with malignant renal lesions. 66.7% (8/12) of these patients had undergone dialysis prior to surgery. We found 10/16 (63%) papillary RCC, 5/16 (31%) clear cell RCC, and 1/16 (6%) papillary noninvasive urothelial cancer. Regarding all renal lesions, 6/17 (35.3%) patients had more than one histological finding in their kidneys. In 2 cases, metachronous metastases were removed. Mean follow-up was 66.7 months.CONCLUSION: Kidney-related prevalence of RCC in ADPKD kidneys was surprisingly high. Whether or not this is due to chronic dialysis or due to the underlying disease is still speculative. Like other cystic renal diseases with an increased risk for RCC, the attending physician should be aware of the malignant potential of ADPKD, especially with concomitant dialysis.

AB - BACKGROUND: The role of autosomal dominant polycystic kidney disease (ADPKD) as a risk factor for renal cell carcinoma (RCC) is still under discussion. Data on prevalence of RCC in ADPKD are limited, especially on a large population scale. The aim of this study was to analyze the prevalence of RCC in ADPKD kidneys and characterize the clinical features of this coincidence.METHODS: Based on our histopathological registry for ADPKD and the Else Kröner-Fresenius Registry, we retrospectively reviewed malignant and benign renal lesions in patients with ADPKD who had undergone renal surgery from 1988 to 2011.RESULTS: 240 ADPKD patients underwent 301 renal surgeries. Mean age at surgery was 54 years. Overall, 16 malignant and 11 benign lesions were analyzed in 301 kidneys (5.3%; 3.7%), meaning that 12/240 (5%; 1:20) patients presented with malignant renal lesions. 66.7% (8/12) of these patients had undergone dialysis prior to surgery. We found 10/16 (63%) papillary RCC, 5/16 (31%) clear cell RCC, and 1/16 (6%) papillary noninvasive urothelial cancer. Regarding all renal lesions, 6/17 (35.3%) patients had more than one histological finding in their kidneys. In 2 cases, metachronous metastases were removed. Mean follow-up was 66.7 months.CONCLUSION: Kidney-related prevalence of RCC in ADPKD kidneys was surprisingly high. Whether or not this is due to chronic dialysis or due to the underlying disease is still speculative. Like other cystic renal diseases with an increased risk for RCC, the attending physician should be aware of the malignant potential of ADPKD, especially with concomitant dialysis.

KW - Carcinoma, Renal Cell

KW - Comorbidity

KW - Female

KW - Germany

KW - Humans

KW - Kidney Neoplasms

KW - Male

KW - Middle Aged

KW - Polycystic Kidney, Autosomal Dominant

KW - Prevalence

KW - Renal Dialysis

KW - Risk Assessment

KW - Journal Article

U2 - 10.1159/000351049

DO - 10.1159/000351049

M3 - Article

C2 - 23752029

VL - 123

SP - 13

EP - 21

JO - Nephron Clinical Practice

JF - Nephron Clinical Practice

SN - 1660-2110

IS - 1-2

ER -

Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens

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