@article{29f7170184d842a482a20cb3e5d3ffb4,
title = "Beta-homo-amino acid scan of angiotensin IV",
abstract = "Angiotensin IV, a metabolite of angiotensin II, inhibits the enzyme insulin regulated aminopeptidase or IRAP and also, although with lower potency, aminopeptidase-N (AP-N). When both beta (2)-homo amino acid- and beta (3)-homo amino acid substitutions were used, allowed the identification of H-( R)beta (2)hVal-Tyr-Ile-His-Pro-beta (3)hPhe-OH as a potent and stable Ang IV analog with high selectivity for IRAP versus AP-N and the AT1 receptor.",
keywords = "Amino Acid Substitution, Amino Acids, Aminopeptidases, Angiotensin II, Animals, Antigens, CD13, Binding Sites, CHO Cells, Cell Line, Cell Membrane, Cricetinae, Cricetulus, Dose-Response Relationship, Drug, Enzyme Activation, Enzyme Inhibitors, Humans, Molecular Structure, Receptor, Angiotensin, Type 1, Structure-Activity Relationship, Research Support, Non-U.S. Gov't",
author = "Aneta Lukaszuk and Heidi Demaegdt and Erzsebet Szemenyei and G{\'e}za T{\'o}th and Dagmara Tymecka and Aleksandra Misicka and Philippe Karoyan and Patrick Vanderheyden and Georges Vauquelin and Dirk Tourw{\'e}",
year = "2008",
month = apr,
day = "10",
doi = "10.1021/jm701490g",
language = "English",
volume = "51",
pages = "2291--2296",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "7",
}