Biomarkers of aging for the identification and evaluation of longevity interventions

Biomarkers of Aging Consortium

doi:10.1016/j.cell.2023.08.003

Biomarkers of aging for the identification and evaluation of longevity interventions

Biomarkers of Aging Consortium

Onderzoeksoutput: Article › peer review

146 Citaten (Scopus)

90 Downloads (Pure)

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With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

Originele taal-2	English
Pagina's (van-tot)	3758-3775
Aantal pagina's	18
Tijdschrift	Cell
Volume	186
Nummer van het tijdschrift	18
DOI's	https://doi.org/10.1016/j.cell.2023.08.003
Status	Published - 31 aug 2023

Bibliografische nota

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10.1016/j.cell.2023.08.003

110029488Accepted author manuscript, 2,66 MBLicentie: CC BY-NC-ND

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2 Actief
4 Afgelopen

IRP22: De Gerontopole Brussel – Expertisecentrum voor Gerontologie aan de Vrije Universiteit Brussel - Centraal thema: Actief en Gezond Ouder Worden
Bautmans, I., Verté, D., Rossi, G., Dierckx, E., Clarys, P., Scafoglieri, A., Quinn, P., Jansen, B., Beckwée, D., Buyl, R. & Engelborghs, S.
1/04/23 → 31/03/28
Project: Fundamenteel
SRP59: SRP-Groeifinanciering: Physical exercise to counteract inflammation in ageing
Bautmans, I., Gutermuth, J. & Njemini, R.
1/03/19 → 31/12/25
Project: Fundamenteel
OZR4026: ERC schrijfmandaat: CLIP-EX: Countering chronic Low-grade Inflammation by Physical Exercise: unraveling muscle–to-immune-cell communication.
Bautmans, I.
1/12/22 → 30/01/24
Project: Fundamenteel

Citeer dit

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title = "Biomarkers of aging for the identification and evaluation of longevity interventions",

abstract = "With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.",

keywords = "Humans, Longevity, Aging, Biomarkers",

author = "{Biomarkers of Aging Consortium} and Mahdi Moqri and Chiara Herzog and Poganik, {Jesse R} and Jamie Justice and Belsky, {Daniel W} and Albert Higgins-Chen and Alexey Moskalev and Georg Fuellen and Cohen, {Alan A} and Ivan Bautmans and Martin Widschwendter and Jingzhong Ding and Alexander Fleming and Joan Mannick and Han, {Jing-Dong Jackie} and Alex Zhavoronkov and Nir Barzilai and Matt Kaeberlein and Steven Cummings and Kennedy, {Brian K} and Luigi Ferrucci and Steve Horvath and Eric Verdin and Maier, {Andrea B} and Snyder, {Michael P} and Vittorio Sebastiano and Gladyshev, {Vadim N}",

year = "2023",

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doi = "10.1016/j.cell.2023.08.003",

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AU - Biomarkers of Aging Consortium

AU - Moqri, Mahdi

AU - Herzog, Chiara

AU - Poganik, Jesse R

AU - Justice, Jamie

AU - Belsky, Daniel W

AU - Higgins-Chen, Albert

AU - Moskalev, Alexey

AU - Fuellen, Georg

AU - Cohen, Alan A

AU - Bautmans, Ivan

AU - Widschwendter, Martin

AU - Ding, Jingzhong

AU - Fleming, Alexander

AU - Mannick, Joan

AU - Han, Jing-Dong Jackie

AU - Zhavoronkov, Alex

AU - Barzilai, Nir

AU - Kaeberlein, Matt

AU - Cummings, Steven

AU - Kennedy, Brian K

AU - Ferrucci, Luigi

AU - Horvath, Steve

AU - Verdin, Eric

AU - Maier, Andrea B

AU - Snyder, Michael P

AU - Sebastiano, Vittorio

AU - Gladyshev, Vadim N

PY - 2023/8/31

Y1 - 2023/8/31

N2 - With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

AB - With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

KW - Humans

KW - Longevity

KW - Aging

KW - Biomarkers

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JO - Cell

JF - Cell

SN - 0092-8674

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ER -

Biomarkers of aging for the identification and evaluation of longevity interventions

Samenvatting

Bibliografische nota

Toegang tot document

Andere bestanden en links

Vingerafdruk

Projecten

IRP22: De Gerontopole Brussel – Expertisecentrum voor Gerontologie aan de Vrije Universiteit Brussel - Centraal thema: Actief en Gezond Ouder Worden

SRP59: SRP-Groeifinanciering: Physical exercise to counteract inflammation in ageing

OZR4026: ERC schrijfmandaat: CLIP-EX: Countering chronic Low-grade Inflammation by Physical Exercise: unraveling muscle–to-immune-cell communication.

Citeer dit