Body composition and blood pressure of 6-year-old singletons born after Pre-implantation Genetic Testing (PGT): a matched cohort study

Florence Belva, M. Roelants, Salome Adriana Kluijfhout, Christiane Winter, Sonja Desmyttere, Andrea Buysse, Pascale De Becker, Martine De Rycke, Willem Verpoest, Ingeborg Liebaers, Mary-Louise Bonduelle

Onderzoeksoutput: Meeting abstract (Journal)


Summary answer: Blood pressure and anthropometric measurements including body mass index (BMI) and indices of peripheral and central adiposity were comparable between PGT and ICSI children. What is known already: Although neonatal outcomes after PGT conception have been found comparable to those after ICSI, few studies have reported on the medical outcome at older ages. We previously found that at age 2, mean body mass index tended to be lower in PGT children while the prevalence of congenital anomalies was similar. Others reported that blood pressure and anthropometrics did not differ in 4- and 9-year old children conceived after IVF/ICSI with or without aneuploidy testing (PGT-A). However, outcomes in PGT-A children cannot be extrapolated to PGT children given the dissimilar indications and parental reproductive background. Study design, size, duration: In this single-center study, singletons conceived by PGT reaching between 5 and 6 years during the period May 2011 and June 2017 were matched as closely as possible for gender, age, maternal educational level and birth order to peers born after ICSI. Biopsy of cleavage-stage embryos was performed solely for the purpose of PGT (PGT-A cycles were excluded) and all fresh embryo transfers in PGT and ICSI cycles were carried out at day 5. Participants/materials, setting, methods: Anthropometrics (weight, height, BMI, skinfold thickness, waist and mid-upper arm circumference) and blood pressure readings of 87 singletons born after PGT, including PGT for mongenic defects (PGT-M) and chromosomal structural rearrangements (PGTSR), but not for aneuploidies (PGT-A), were compared with results of 87 peers born after ICSI. Main results and the role of chance: From the 124 eligible PGD families, 110 could be contacted, 23 declined and 87 (70.2%) children participated of whom 39 (45%) were males. The reasons for declining were ‘no time’ and ‘living too far from the hospital’. Neonatal characteristics, including birth weight Standard Deviation Score (SDS) and gestational age and parental characteristics, including maternal weight gain, smoking and alcohol consumption during pregnancy, maternal age, current maternal and paternal BMI were comparable between the groups (all p > 0.05). Mean age was 5.5 years in the PGT group and 5.6 years in the ICSI group (P = 0.2). All anthropometric measurements, including BMI SDS, waist and mid-upper arm circumference SDS were comparable between the PGT (-0.23; 0.27; 0.17 respectively) and ICSI (-0.29; 0.10; 0.11) group (all P > 0.05). Furthermore, skin thickness derived indices of peripheral and central adiposity were comparable (PGT: 14.7mm; 11.6mm and ICSI: 15.5mm; 11.5mm) as well as the calculated total body fat mass (PGT: 13.7% and ICSI: 13.9%) (all P > 0.05). Finally, also blood pressure SDS were comparable between the two groups (all P > 0.05). Results did not change taking neonatal (birth weight SDS, gestational age, birth order) and parental (pre-pregnancy maternal BMI, maternal educational level) characteristics into account. Limitations, reasons for caution: The non-participating PGT children did not differ from the participating group in terms of gender, birth order, gestational age, birth weight or maternal educational level, which makes participation bias less likely. Wider implications of the findings: Our results point to no adverse effect of embryo biopsy at cleavage-stage and fresh embryo transfer at day 5. However, more and long-term follow-up studies are indicated as there are currently no data available for PGT children born after trophectoderm biopsy and/ or transfer of warmed embryos after vitrification. Trial registration number: not applicable. Abstracts of the 34th Annual Meeting of the ESHRE, Barcelona, Spain 1 to 4 July 2018 i31
Originele taal-2English
Pagina's (van-tot)31-31
Aantal pagina's1
TijdschriftHum Reprod
Nummer van het tijdschriftSuppl
StatusPublished - 2018
EvenementESHRE 2018 - CCIB, Barcelona, Spain
Duur: 2 jul 20184 jul 2018


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