Breast conserving treatment for breast cancer: dosimetric comparison of sequential versus simultaneous integrated photon boost

Hilde Van Parijs, Truus Reynders, Karina Heuninckx, Dirk Verellen, Guy Storme, Mark De Ridder

Onderzoeksoutput: Article

16 Citaten (Scopus)

Samenvatting

BACKGROUND: Breast conserving surgery followed by whole breast irradiation is widely accepted as standard of care for early breast cancer. Addition of a boost dose to the initial tumor area further reduces local recurrences. We investigated the dosimetric benefits of a simultaneously integrated boost (SIB) compared to a sequential boost to hypofractionate the boost volume, while maintaining normofractionation on the breast.

METHODS: For 10 patients 4 treatment plans were deployed, 1 with a sequential photon boost, and 3 with different SIB techniques: on a conventional linear accelerator, helical TomoTherapy, and static TomoDirect. Dosimetric comparison was performed.

RESULTS: PTV-coverage was good in all techniques. Conformity was better with all SIB techniques compared to sequential boost (P = 0.0001). There was less dose spilling to the ipsilateral breast outside the PTVboost (P = 0.04). The dose to the organs at risk (OAR) was not influenced by SIB compared to sequential boost. Helical TomoTherapy showed a higher mean dose to the contralateral breast, but less than 5 Gy for each patient.

CONCLUSIONS: SIB showed less dose spilling within the breast and equal dose to OAR compared to sequential boost. Both helical TomoTherapy and the conventional technique delivered acceptable dosimetry. SIB seems a safe alternative and can be implemented in clinical routine.

Originele taal-2English
Artikelnummer827475
Aantal pagina's8
TijdschriftBioMed Research International
Volume2014
DOI's
StatusPublished - 2014

Keywords

  • Breast Neoplasms
  • Female
  • Humans
  • Mastectomy, Segmental
  • Photons
  • Radiation Dosage
  • Radiotherapy, Intensity-Modulated

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