Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein

Olga Rusyakina, Thomas Geernaert, Médéric Loyez, Maxime Lobry, Karima Chah, Pawel Mergo, Hugo Thienpont, Christophe Caucheteur, Francis Berghmans, Tigran Baghdasaryan

Onderzoeksoutput: Articlepeer review

1 Citaat (Scopus)
74 Downloads (Pure)

Samenvatting

Spectral multiplexing of biosensors in a single optical fiber has been a long-standing challenge, which we address here for the first time by combining photonic crystal fibers (PCF) with fiber Bragg grating technology. We exploit the features of the optical transmission spectrum of a straight fiber Bragg grating written in a PCF that allows exciting cladding mode resonances within a spectral span of about 60 nm, which is significantly narrower than the width of the transmission spectra of tilted gratings in standard single-mode step-index fibers. More specifically, we consider the cladding mode resonances that feature effective index values close to the refractive index of phosphate buffered saline, and we demonstrate plasmonic label-free biodetection of HER2 (human epidermal growth factor receptor 2) protein. We report on the simultaneous monitoring of the wavelength shifts of said cladding mode resonances from two spatially separated biofunctionalized Bragg gratings and we find that the PCF sensor is able to detect the protein concentration of 8.62 nM with high reproducibility.
Originele taal-2English
Artikelnummer133561
Pagina's (van-tot)1-10
Aantal pagina's10
TijdschriftSensors and Actuators B: Chemical
Volume382
DOI's
StatusPublished - 1 mei 2023

Bibliografische nota

Funding Information:
This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS). The approach for an external refractometry and biosensing with PCFs with their multiplexing capability has been published on April 7th, 2022, as a patent application entitled “Microstructured optical fiber sensing device” under an international publication number WO 2022/069687 A1. Supplementary data. The file with supplementary data is available online.

Funding Information:
This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem ; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS).

Publisher Copyright:
© 2023

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

Vingerafdruk

Duik in de onderzoeksthema's van 'Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein'. Samen vormen ze een unieke vingerafdruk.

Citeer dit