Case study: Angiotensin receptor blockers (ARBs)

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    here is now also ample evidence that the "residence time" of a drug at it cellular target (such as a receptor or an enzyme) may affect its clinical performance. In this respect, a great deal of attention has been devoted to those situations in where optimal clinical performance requires continuing, high levels of target occupancy. This has for example been proposed to be the case with AT1 receptor antagonist candesartan.
    Originele taal-2English
    TitelKinetics and Thermodynamics of Drug binding
    RedacteurenKeserü G., Swinney D.
    Plaats van productieGermany
    Aantal pagina's21
    ISBN van geprinte versie978-3-527-33582-4
    StatusPublished - 2015

    Publicatie series

    NaamWiley's Methods and Principles in Medicinal Chemistry Series

    Bibliografische nota

    Keserü G. and Swinney D.


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