Cellular immunotherapy in multiple myeloma: Lessons from preclinical models

Marilene Binsfeld, Karel Fostier, J. Muller, F. Baron, Henri Schots, Yves Beguin, R Heusschen, Jo Caers

Onderzoeksoutput: Articlepeer review

18 Citaten (Scopus)


The majority of multiple myeloma patients relapse with the current treatment strategies, raising the need for alternative therapeutic approaches. Cellular immunotherapy is a rapidly evolving field and currently being translated into clinical trials with encouraging results in several cancer types, including multiple myeloma. Murine multiple myeloma models are of critical importance for the development and refinement of cellular immunotherapy. In this review, we summarize the immune cell changes that occur in multiple myeloma patients and we discuss the cell-based immunotherapies that have been tested in multiple myeloma, with a focus on murine models.
Originele taal-2English
Pagina's (van-tot)392-404
TijdschriftBiochimica et Biophysica Acta - Reviews on Cancer
Nummer van het tijdschrift2
StatusPublished - 7 aug 2014


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