Central haemodynamic abnormalities and outcome in patients with unexplained dyspnoea

Kazunori Omote, Frederik H Verbrugge, Hidemi Sorimachi, Massar Omar, Dejana Popovic, Masaru Obokata, Yogesh N V Reddy, Barry A Borlaug

Onderzoeksoutput: Articlepeer review

38 Citaten (Scopus)

Samenvatting

Aims: Little data are available regarding prognostic implications of invasive exercise testing in heart failure with preserved ejection fraction (HFpEF). The present study aimed to investigate whether rest and exercise central haemodynamic abnormalities are associated with adverse clinical outcomes in patients with dyspnea. Methods and results: Patients with exertional dyspnoea and ejection fraction ≥50% (n = 764) underwent invasive exercise testing and follow-up for heart failure hospitalization or death. There were 117 patients with events over a median follow-up of 2.7 (interquartile range 0.5–4.6) years. Among patients with normal resting pulmonary artery wedge pressure (PAWP) (<15 mmHg, n = 380 [50%]), increased exercise PAWP (≥25 mmHg) was present in 187 (24% of cohort) and was associated with 2.4-fold higher risk of events compared to those with normal exercise PAWP (<25 mmHg, n = 193 [25%]) (hazard ratio [HR] 2.44; 95% confidence interval [CI] 1.11–5.36; p = 0.03), while patients with elevated resting PAWP (≥15 mmHg, n = 384 [50%]) displayed even higher risk compared to HFpEF with normal resting PAWP (HR 2.24; 95% CI 1.38–3.65; p = 0.001). Similar findings were observed for rest/exercise right atrial pressure, and rest/exercise pulmonary artery pressures. Higher peak oxygen consumption was associated with decreased risk of events, and this relationship was solely explained by exercise cardiac output. In a multivariable-adjusted Cox model, each 1 standard deviation (SD) increase in exercise PAWP was associated with a 41% greater hazard of events (HR 1.41; 95% CI 1.13–1.76; p = 0.002), while each 1 SD decrease in exercise cardiac output was associated with a 37% increased risk (HR 0.63; 95% CI 0.47–0.83; p = 0.001). Conclusions: Haemodynamic abnormalities currently used for diagnosis of HFpEF are associated with increased risk for adverse events. Treatments that reduce central pressures while improving cardiac output reserve may offer greatest benefit to improve outcomes in HFpEF.

Originele taal-2English
Pagina's (van-tot)185-196
Aantal pagina's12
TijdschriftEuropean Journal of Heart Failure
Volume25
Nummer van het tijdschrift2
Vroegere onlinedatum15 dec 2022
DOI's
StatusPublished - feb 2023

Bibliografische nota

Funding Information:
Barry A. Borlaug is supported by R01 HL128526 and U01 HL160226 from the NHLBI and W81XWH2210245 from the United States Department of Defense. Hidemi Sorimachi is supported by a research fellowship from the Uehara Memorial Foundation, Japan. Kazunori Omote is supported by Japan Heart Foundation/Bayer Yakuhin Research Grant Abroad and the JSPS Overseas Research Fellowships from the Japan Society for the Promotion of Science. Frederik H. Verbrugge is supported by a Fellowship of the Belgian American Educational Foundation (BAEF) and by the Special Research Fund (BOF) of Hasselt University (BOF19PD04).

Publisher Copyright:
© 2022 European Society of Cardiology.

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

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