Characteristics of patients with atrial fibrillation prescribed edoxaban in Belgium and The Netherlands: insights from the ETNA-AF-Europe study

ETNA-AF-Europe principal investigators from Belgium and the Netherlands, Tim A C de Vries, Martin E W Hemels, Frank Cools, Harry J G M Crijns, Laetitia Yperzeele, Peter Vanacker, Ivan Blankoff, Patrizio Lancellotti, Georges H Mairesse, Anne de Veer, Ruben Casado Arroyo, Emmanuel Catez, Michel de Pauw, Thomas Vanassche, Carlo de Asmundis, Paulus Kirchhof, Raffaele De Caterina, Joris R de Groot

Onderzoeksoutput: Article

Samenvatting

BACKGROUND: Studies on the use of non-vitamin K antagonist oral anticoagulants in unselected patients with atrial fibrillation (AF) show that clinical characteristics and dosing practices differ per region, but lack data on edoxaban.

METHODS: With data from Edoxaban Treatment in routiNe clinical prActice for patients with AF in Europe (ETNA-AF-Europe), a large prospective observational study, we compared clinical characteristics (including the dose reduction criteria for edoxaban: creatinine clearance 15-50 mL/min, weight ≤60 kg, and/or use of strong p-glycoprotein inhibitors) of patients from Belgium and the Netherlands (BeNe) with those from other European countries (OEC).

RESULTS: Of all 13,639 patients in ETNA-AF-Europe, 2579 were from BeNe. BeNe patients were younger than OEC patients (mean age: 72.3 vs 73.9 years), and had lower CHA2DS2-VASc (mean: 2.8 vs 3.2) and HAS-BLED scores (mean: 2.4 vs 2.6). Patients from BeNe less often had hypertension (61.6% vs 80.4%), and/or diabetes mellitus (17.3% vs 23.1%) than patients from OEC. Moreover, relatively fewer patients in BeNe were prescribed the reduced dose of 30 mg edoxaban (14.8%) than in OEC (25.4%). Overall, edoxaban was dosed according to label in 83.1% of patients. Yet, 30 mg edoxaban was prescribed in the absence of any dose reduction criteria in 36.9% of 30 mg users (5.5% of all patients) in BeNe compared with 35.5% (9.0% of all patients) in OEC.

CONCLUSION: There were several notable differences between BeNe and OEC regarding clinical characteristics and dosing practices in patients prescribed edoxaban, which are relevant for the local implementation of dose evaluation and optimisation.

TRIAL REGISTRATION: NCT02944019; Date of registration: October 24, 2016.

Originele taal-2English
Pagina's (van-tot)431-439
Aantal pagina's9
TijdschriftActa Cardiologica
Volume76
Nummer van het tijdschrift4
Vroegere onlinedatum7 jan 2021
DOI's
StatusPublished - 4 jul 2021

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