Projecten per jaar
Samenvatting
Introduction: The evaluation of the potential carcinogenicity is a key consideration in the risk assessment of chemicals. Predictive toxicology is currently switching towards non-animal approaches that rely on the mechanistic understanding of toxicity. Areas covered: Adverse outcome pathways (AOPs) present toxicological processes, including chemical-induced carcinogenicity, in a visual and comprehensive manner, which serve as the conceptual backbone for the development of non-animal approaches eligible for hazard identification. The current review provides an overview of the available AOPs leading to liver cancer and discusses their use in advanced testing of liver carcinogenic chemicals. Moreover, the challenges related to their use in risk assessment are outlined, including the exploitation of available data, the need for semantic ontologies, and the development of quantitative AOPs. Expert Opinion: To exploit the potential of liver cancer AOPs in the field of risk assessment, 3 immediate prerequisites need to be fulfilled. These include developing human relevant AOPs for chemical-induced liver cancer, increasing the number of AOPs integrating quantitative toxicodynamic and toxicokinetic data, and developing a liver cancer AOP network. As AOPs and other areas in the field continue to evolve, liver cancer AOPs will progress into a reliable and robust tool serving future risk assessment and management.
Originele taal-2 | English |
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Pagina's (van-tot) | 425-438 |
Aantal pagina's | 19 |
Tijdschrift | Expert Opinion on Drug Safety |
Volume | 23 |
Nummer van het tijdschrift | 4 |
DOI's | |
Status | Published - 4 apr 2024 |
Bibliografische nota
Publisher Copyright:© 2024 Informa UK Limited, trading as Taylor & Francis Group.
Vingerafdruk
Duik in de onderzoeksthema's van 'Chemical-induced liver cancer: an adverse outcome pathway perspective'. Samen vormen ze een unieke vingerafdruk.Projecten
- 2 Actief
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FWOAL1070: De rol van pannexine1 kanalen in niet-alcoholische steatohepatitis: therapeutische en diagnostische relevantie.
1/01/23 → 31/12/26
Project: Fundamenteel
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FWOAL1047: Kunnen voedingsadditieven leverschade veroorzaken? Een mechanistische in vitro modellering studie.
1/01/22 → 31/12/25
Project: Fundamenteel