Childhood Leukaemia incidence around the Belgian nuclear sites: Surrogate exposure modelling

Koen Simons; Kaatje Bollaerts; Michel Sonck; Fierens Sébastien; André Poffijn; Lodewijk Van Bladel; David Geraerts; Pol Gosselin; Herman Van Oyen; Julie Francart; An Van Nieuwenhuyse

Childhood Leukaemia incidence around the Belgian nuclear sites: Surrogate exposure modelling

Koen Simons, Kaatje Bollaerts, Michel Sonck, Fierens Sébastien, André Poffijn, Lodewijk Van Bladel, David Geraerts, Pol Gosselin, Herman Van Oyen, Julie Francart, An Van Nieuwenhuyse

Onderzoeksoutput: Conference paper › Research

Samenvatting

Health eects among populations living in the vicinity of nuclear installations have been a major area of concern for several decades already. The main focus is on childhood leukaemia. The dominant approach is an ecological study using residential proximity to the nuclear site, however complex radioactive discharge models have also been used. This paper describes an ecological study on leukaemia incidence in children living in the vicinity of nuclear installations in Belgium. Each nuclear site was treated as a point-source and single-site focussed hypothesis tests were used to test for a gradient in childhood leukaemia incidence with residential proximity to the site. In addition, two other surrogate exposures were used: prevailing wind direction and simulated radioactive discharges. The use of multiple measures of surrogate exposures and multiple statistical methods has added value when investigating a priori defined pointsources.

Originele taal-2	English
Titel	Proceedings of the 28th International Workshop on Statistical Modelling
Subtitel	July 8 - 12, 2013 Palermo, Italy
Redacteuren	Vito M.R. Muggeo, Vincenza Capursi, Giovanni Boscaino, Gianfranco Lovison
Pagina's	773-778
Aantal pagina's	5
Status	Published - mei 2013
Evenement	International Workshop on Statistical Modelling - Sicily, Palermo, Italy Duur: 8 jul 2013 → 12 aug 2013

Conference

Conference	International Workshop on Statistical Modelling
Land/Regio	Italy
Stad	Palermo
Periode	8/07/13 → 12/08/13

Keywords

Childhood Leukaemia
Nuclear Sites
Surrogate-Exposure Modelling

3 Article
1 Meeting abstract (Book)

Childhood Leukaemia near Nuclear Sites in Belgium, 2002-2008
Bollaerts, K., Simons, K., Van Bladel, L., De Smedt, T., Sonck, M., Fierens, S., Poffijn, A., Geraerts, D., Gosselin, P., Van Oyen, H., Francart, J. & Van Nieuwenhuyse, A., 30 mei 2016, (Accepted/In press) In: European Journal of Cancer Prevention.
Onderzoeksoutput: Article › peer review
3 Citaten (Scopus)
Thyroid cancer incidence around the Belgian nuclear sites: Surrogate exposure modelling
Bollaerts, K., Sonck, M., Simons, K., Sébastien, F., Poffijn, A., Van Bladel, L., Geraerts, D., Gosselin, P., Van Oyen, H., Francart, J. & Van Nieuwenhuyse, A., 2015, In: Cancer Epidemiol. 39, blz. 48-54 7 blz.
Onderzoeksoutput: Article › peer review

Open Access
Thyroid Cancer Incidence around the Belgian Nuclear Sites: Surrogate Exposure Modeling
Simons, K., 16 mei 2015, BIT's 8th Annual World Cancer Congress 2015. blz. 68 1 blz.
Onderzoeksoutput: Meeting abstract (Book)

1 Participation in conference

International Workshop on Statistical Modelling
Koen Simons (Participant)
8 jul 2013 → 12 jul 2013
Activiteit: Participation in conference

Citeer dit

Simons, K., Bollaerts, K., Sonck, M., Sébastien, F., Poffijn, A., Van Bladel, L., Geraerts, D., Gosselin, P., Van Oyen, H., Francart, J., & Van Nieuwenhuyse, A. (2013). Childhood Leukaemia incidence around the Belgian nuclear sites: Surrogate exposure modelling. In V. M. R. Muggeo, V. Capursi, G. Boscaino, & G. Lovison (editors), Proceedings of the 28th International Workshop on Statistical Modelling: July 8 - 12, 2013 Palermo, Italy (blz. 773-778)

Simons, Koen ; Bollaerts, Kaatje ; Sonck, Michel ; Sébastien, Fierens ; Poffijn, André ; Van Bladel, Lodewijk ; Geraerts, David ; Gosselin, Pol ; Van Oyen, Herman ; Francart, Julie ; Van Nieuwenhuyse, An. / Childhood Leukaemia incidence around the Belgian nuclear sites : Surrogate exposure modelling. Proceedings of the 28th International Workshop on Statistical Modelling: July 8 - 12, 2013 Palermo, Italy. redacteur / Vito M.R. Muggeo ; Vincenza Capursi ; Giovanni Boscaino ; Gianfranco Lovison. 2013. blz. 773-778

@inproceedings{0d62f97636af4f8e9110b4441bc925aa,

title = "Childhood Leukaemia incidence around the Belgian nuclear sites: Surrogate exposure modelling",

abstract = "Background: Health eects among populations living in the vicinity of nuclear installations have been a major area of concern for several decadesalready. The main focus is on childhood leukaemia. The dominant approach is an ecological study using residential proximity to the nuclear site, however complexradio-active discharge models have also been used.Data: The Belgian Cancer Registry provided data on Childhood leukaemia incidence by commune, age and sex. For the Flemish region this data spans theincidence years 2000-08; for the Walloon and Brussels-Capital Region the data span 2004-08. The study considers four nuclear sites. For each site, the FederalAgency for Nuclear Control used survey stations to measure wind direction and velocity for the period 2003-08.Methods: This paper describes an ecological study on leukaemia incidence in children living in the vicinity of nuclear installations in Belgium. Each nuclear sitewas treated as a point-source and single-site focussed hypothesis tests were used to test for a gradient in childhood leukaemia incidence with residential proximityto the site. In addition, two other surrogate exposures were used: prevailing wind direction and simulated radioactive discharges. The hypothesis tests were com-plemented by estimating the shape of the exposure-response relationship using Generalized Additive Models.Results: For the nuclear power plants of Doel and Tihange, no evidence of a gradient in childhood leukaemia cancer incidence related to any surrogate exposurewas found. For the nuclear research- and industry sites of Mol-Dessel and Fleurus, individual tests were less uniform. Only for Mol-Dessel it can be concludedthat the evidence may be suggestive of a potential association with the site.Conclusions: The use of multiple measures of surrogate exposures and multiple statistical methods has added value when investigating a priori dened point-sources. Each surrogate has implicit assumptions and precision and each statistical method relies on its own assumptions. By combining and comparing theresults of multiple approaches, new insights can be gained. However, it should be noted that the results are still subject to the limitations of the ecological design.",

keywords = "Childhood Leukaemia, Nuclear Sites, Surrogate-Exposure Modelling",

author = "Koen Simons and Kaatje Bollaerts and Michel Sonck and Fierens S{\'e}bastien and Andr{\'e} Poffijn and {Van Bladel}, Lodewijk and David Geraerts and Pol Gosselin and {Van Oyen}, Herman and Julie Francart and {Van Nieuwenhuyse}, An",

year = "2013",

month = may,

language = "English",

isbn = "978-88-96251-49-2",

pages = "773--778",

editor = "Muggeo, {Vito M.R.} and Vincenza Capursi and Giovanni Boscaino and Gianfranco Lovison",

booktitle = "Proceedings of the 28th International Workshop on Statistical Modelling",

note = "International Workshop on Statistical Modelling ; Conference date: 08-07-2013 Through 12-08-2013",

}

Simons, K, Bollaerts, K, Sonck, M, Sébastien, F, Poffijn, A, Van Bladel, L, Geraerts, D, Gosselin, P, Van Oyen, H, Francart, J & Van Nieuwenhuyse, A 2013, Childhood Leukaemia incidence around the Belgian nuclear sites: Surrogate exposure modelling. in VMR Muggeo, V Capursi, G Boscaino & G Lovison (redactie), Proceedings of the 28th International Workshop on Statistical Modelling: July 8 - 12, 2013 Palermo, Italy. blz. 773-778, International Workshop on Statistical Modelling, Palermo, Italy, 8/07/13.

Childhood Leukaemia incidence around the Belgian nuclear sites : Surrogate exposure modelling. / Simons, Koen; Bollaerts, Kaatje; Sonck, Michel; Sébastien, Fierens; Poffijn, André; Van Bladel, Lodewijk; Geraerts, David; Gosselin, Pol; Van Oyen, Herman; Francart, Julie; Van Nieuwenhuyse, An.

Proceedings of the 28th International Workshop on Statistical Modelling: July 8 - 12, 2013 Palermo, Italy. redactie / Vito M.R. Muggeo; Vincenza Capursi; Giovanni Boscaino; Gianfranco Lovison. 2013. blz. 773-778.

Onderzoeksoutput: Conference paper › Research

TY - GEN

T1 - Childhood Leukaemia incidence around the Belgian nuclear sites

T2 - International Workshop on Statistical Modelling

AU - Simons, Koen

AU - Bollaerts, Kaatje

AU - Sonck, Michel

AU - Sébastien, Fierens

AU - Poffijn, André

AU - Van Bladel, Lodewijk

AU - Geraerts, David

AU - Gosselin, Pol

AU - Van Oyen, Herman

AU - Francart, Julie

AU - Van Nieuwenhuyse, An

PY - 2013/5

Y1 - 2013/5

N2 - Background: Health eects among populations living in the vicinity of nuclear installations have been a major area of concern for several decadesalready. The main focus is on childhood leukaemia. The dominant approach is an ecological study using residential proximity to the nuclear site, however complexradio-active discharge models have also been used.Data: The Belgian Cancer Registry provided data on Childhood leukaemia incidence by commune, age and sex. For the Flemish region this data spans theincidence years 2000-08; for the Walloon and Brussels-Capital Region the data span 2004-08. The study considers four nuclear sites. For each site, the FederalAgency for Nuclear Control used survey stations to measure wind direction and velocity for the period 2003-08.Methods: This paper describes an ecological study on leukaemia incidence in children living in the vicinity of nuclear installations in Belgium. Each nuclear sitewas treated as a point-source and single-site focussed hypothesis tests were used to test for a gradient in childhood leukaemia incidence with residential proximityto the site. In addition, two other surrogate exposures were used: prevailing wind direction and simulated radioactive discharges. The hypothesis tests were com-plemented by estimating the shape of the exposure-response relationship using Generalized Additive Models.Results: For the nuclear power plants of Doel and Tihange, no evidence of a gradient in childhood leukaemia cancer incidence related to any surrogate exposurewas found. For the nuclear research- and industry sites of Mol-Dessel and Fleurus, individual tests were less uniform. Only for Mol-Dessel it can be concludedthat the evidence may be suggestive of a potential association with the site.Conclusions: The use of multiple measures of surrogate exposures and multiple statistical methods has added value when investigating a priori dened point-sources. Each surrogate has implicit assumptions and precision and each statistical method relies on its own assumptions. By combining and comparing theresults of multiple approaches, new insights can be gained. However, it should be noted that the results are still subject to the limitations of the ecological design.

AB - Background: Health eects among populations living in the vicinity of nuclear installations have been a major area of concern for several decadesalready. The main focus is on childhood leukaemia. The dominant approach is an ecological study using residential proximity to the nuclear site, however complexradio-active discharge models have also been used.Data: The Belgian Cancer Registry provided data on Childhood leukaemia incidence by commune, age and sex. For the Flemish region this data spans theincidence years 2000-08; for the Walloon and Brussels-Capital Region the data span 2004-08. The study considers four nuclear sites. For each site, the FederalAgency for Nuclear Control used survey stations to measure wind direction and velocity for the period 2003-08.Methods: This paper describes an ecological study on leukaemia incidence in children living in the vicinity of nuclear installations in Belgium. Each nuclear sitewas treated as a point-source and single-site focussed hypothesis tests were used to test for a gradient in childhood leukaemia incidence with residential proximityto the site. In addition, two other surrogate exposures were used: prevailing wind direction and simulated radioactive discharges. The hypothesis tests were com-plemented by estimating the shape of the exposure-response relationship using Generalized Additive Models.Results: For the nuclear power plants of Doel and Tihange, no evidence of a gradient in childhood leukaemia cancer incidence related to any surrogate exposurewas found. For the nuclear research- and industry sites of Mol-Dessel and Fleurus, individual tests were less uniform. Only for Mol-Dessel it can be concludedthat the evidence may be suggestive of a potential association with the site.Conclusions: The use of multiple measures of surrogate exposures and multiple statistical methods has added value when investigating a priori dened point-sources. Each surrogate has implicit assumptions and precision and each statistical method relies on its own assumptions. By combining and comparing theresults of multiple approaches, new insights can be gained. However, it should be noted that the results are still subject to the limitations of the ecological design.

KW - Childhood Leukaemia

KW - Nuclear Sites

KW - Surrogate-Exposure Modelling

M3 - Conference paper

SN - 978-88-96251-49-2

SN - 978-88-96251-47-8

SP - 773

EP - 778

BT - Proceedings of the 28th International Workshop on Statistical Modelling

A2 - Muggeo, Vito M.R.

A2 - Capursi, Vincenza

A2 - Boscaino, Giovanni

A2 - Lovison, Gianfranco

Y2 - 8 July 2013 through 12 August 2013

ER -

Childhood Leukaemia incidence around the Belgian nuclear sites: Surrogate exposure modelling

Samenvatting

Conference

Keywords

Vingerafdruk

Onderzoekersoutput

Childhood Leukaemia near Nuclear Sites in Belgium, 2002-2008

Thyroid cancer incidence around the Belgian nuclear sites: Surrogate exposure modelling

Thyroid Cancer Incidence around the Belgian Nuclear Sites: Surrogate Exposure Modeling

Activiteiten

International Workshop on Statistical Modelling

Citeer dit