Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

Claudia Spits; Joke Mertens; Florence Belva; Aafke PA van Montfoort; Marius Regin; Filippo Zambelli; Sara Seneca; Edouard Couvreu De Deckersberg; Mary-Louise Bonduelle; Herman Tournaye; Katrien Stouffs; Kurt Barbé; Bert Smeets; Hilde Van De Velde; Karen Sermon; Christophe Blockeel

doi:10.1038/s41467-024-45446-1

Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

Claudia Spits, Joke Mertens, Florence Belva, Aafke PA van Montfoort, Marius Regin, Filippo Zambelli, Sara Seneca, Edouard Couvreu De Deckersberg, Mary-Louise Bonduelle, Herman Tournaye, Katrien Stouffs, Kurt Barbé, Bert Smeets, Hilde Van De Velde, Karen Sermon, Christophe Blockeel

Onderzoeksoutput: Article › peer review

2 Citaten (Scopus)

7 Downloads (Pure)

Samenvatting

Children conceived through assisted reproductive technologies (ART) have an elevated risk of lower birthweight, yet the underlying cause remains unclear. Our study explores mitochondrial DNA (mtDNA) variants as contributors to birthweight differences by impacting mitochondrial function during prenatal development. We deep-sequenced the mtDNA of 451 ART and spontaneously conceived (SC) individuals, 157 mother-child pairs and 113 individual oocytes from either natural menstrual cycles or after ovarian stimulation (OS) and find that ART individuals carried a different mtDNA genotype than SC individuals, with more de novo non-synonymous variants. These variants, along with rRNA variants, correlate with lower birthweight percentiles, independent of conception mode. Their higher occurrence in ART individuals stems from de novo mutagenesis associated with maternal aging and OS-induced oocyte cohort size. Future research will establish the long-term health consequences of these changes and how these findings will impact the clinical practice and patient counselling in the future.

Originele taal-2	English
Artikelnummer	1232
Aantal pagina's	16
Tijdschrift	Nature Communications
Volume	15
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1038/s41467-024-45446-1
Status	Published - 9 feb 2024

Bibliografische nota

Publisher Copyright:
© 2024. The Author(s).

Toegang tot document

10.1038/s41467-024-45446-1Licentie: CC BY

108410130Final published version, 2,13 MBLicentie: CC BY

Andere bestanden en links

Link naar publicatie in Scopus

1 Actief
5 Afgelopen

OZRMETH9: De genetische component in infertiliteit en mislukking van vroege menselijke ontwikkeling
Sermon, K. & Spits, C.
1/01/23 → 31/12/29
Project: Fundamenteel
FWOTM968: De zoektocht naar de oorsprong van chromosomale afwijkingen in menselijke pre-implantatie-embryo's
Sermon, K., Spits, C. & Regin, M.
1/10/19 → 31/10/23
Project: Fundamenteel
FWOSB55: De weg naar een veilige introductie van hESC in de kliniek: de casus van genetisch mozaicisme in hESC-afgeleide retinale cellen
Couvreu De Deckersberg, E., Spits, C. & Sermon, K.
1/01/19 → 31/12/22
Project: Fundamenteel

Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight
Spits, C. (Creator), figshare, 2024
DOI: https://doi.org/10.6084/m9.figshare.24126525.v1
Dataset

Citeer dit

Spits, C., Mertens, J., Belva, F., van Montfoort, A. PA., Regin, M., Zambelli, F., Seneca, S., Couvreu De Deckersberg, E., Bonduelle, M-L., Tournaye, H., Stouffs, K., Barbé, K., Smeets, B., Van De Velde, H., Sermon, K., & Blockeel, C. (2024). Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight. Nature Communications, 15(1), [1232 ]. https://doi.org/10.1038/s41467-024-45446-1

Spits, Claudia ; Mertens, Joke ; Belva, Florence ; van Montfoort, Aafke PA ; Regin, Marius ; Zambelli, Filippo ; Seneca, Sara ; Couvreu De Deckersberg, Edouard ; Bonduelle, Mary-Louise ; Tournaye, Herman ; Stouffs, Katrien ; Barbé, Kurt ; Smeets, Bert ; Van De Velde, Hilde ; Sermon, Karen ; Blockeel, Christophe. / Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight. In: Nature Communications. 2024 ; Vol. 15, Nr. 1.

@article{910268af60e848b2be1b40146aad8b33,

title = "Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight",

abstract = "Children conceived through assisted reproductive technologies (ART) have an elevated risk of lower birthweight, yet the underlying cause remains unclear. Our study explores mitochondrial DNA (mtDNA) variants as contributors to birthweight differences by impacting mitochondrial function during prenatal development. We deep-sequenced the mtDNA of 451 ART and spontaneously conceived (SC) individuals, 157 mother-child pairs and 113 individual oocytes from either natural menstrual cycles or after ovarian stimulation (OS) and find that ART individuals carried a different mtDNA genotype than SC individuals, with more de novo non-synonymous variants. These variants, along with rRNA variants, correlate with lower birthweight percentiles, independent of conception mode. Their higher occurrence in ART individuals stems from de novo mutagenesis associated with maternal aging and OS-induced oocyte cohort size. Future research will establish the long-term health consequences of these changes and how these findings will impact the clinical practice and patient counselling in the future.",

author = "Claudia Spits and Joke Mertens and Florence Belva and {van Montfoort}, {Aafke PA} and Marius Regin and Filippo Zambelli and Sara Seneca and {Couvreu De Deckersberg}, Edouard and Mary-Louise Bonduelle and Herman Tournaye and Katrien Stouffs and Kurt Barb{\'e} and Bert Smeets and {Van De Velde}, Hilde and Karen Sermon and Christophe Blockeel",

note = "Publisher Copyright: {\textcopyright} 2024. The Author(s).",

year = "2024",

month = feb,

day = "9",

doi = "10.1038/s41467-024-45446-1",

language = "English",

volume = "15",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

Spits, C , Mertens, J , Belva, F, van Montfoort, APA, Regin, M, Zambelli, F, Seneca, S , Couvreu De Deckersberg, E , Bonduelle, M-L , Tournaye, H , Stouffs, K , Barbé, K, Smeets, B, Van De Velde, H , Sermon, K & Blockeel, C 2024, 'Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight', Nature Communications, vol. 15, nr. 1, 1232 . https://doi.org/10.1038/s41467-024-45446-1

Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight. / Spits, Claudia ; Mertens, Joke ; Belva, Florence; van Montfoort, Aafke PA; Regin, Marius; Zambelli, Filippo; Seneca, Sara ; Couvreu De Deckersberg, Edouard ; Bonduelle, Mary-Louise ; Tournaye, Herman ; Stouffs, Katrien ; Barbé, Kurt; Smeets, Bert; Van De Velde, Hilde ; Sermon, Karen ; Blockeel, Christophe.

In: Nature Communications, Vol. 15, Nr. 1, 1232 , 09.02.2024.

Onderzoeksoutput: Article › peer review

TY - JOUR

T1 - Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

AU - Spits, Claudia

AU - Mertens, Joke

AU - Belva, Florence

AU - van Montfoort, Aafke PA

AU - Regin, Marius

AU - Zambelli, Filippo

AU - Seneca, Sara

AU - Couvreu De Deckersberg, Edouard

AU - Bonduelle, Mary-Louise

AU - Tournaye, Herman

AU - Stouffs, Katrien

AU - Barbé, Kurt

AU - Smeets, Bert

AU - Van De Velde, Hilde

AU - Sermon, Karen

AU - Blockeel, Christophe

PY - 2024/2/9

Y1 - 2024/2/9

N2 - Children conceived through assisted reproductive technologies (ART) have an elevated risk of lower birthweight, yet the underlying cause remains unclear. Our study explores mitochondrial DNA (mtDNA) variants as contributors to birthweight differences by impacting mitochondrial function during prenatal development. We deep-sequenced the mtDNA of 451 ART and spontaneously conceived (SC) individuals, 157 mother-child pairs and 113 individual oocytes from either natural menstrual cycles or after ovarian stimulation (OS) and find that ART individuals carried a different mtDNA genotype than SC individuals, with more de novo non-synonymous variants. These variants, along with rRNA variants, correlate with lower birthweight percentiles, independent of conception mode. Their higher occurrence in ART individuals stems from de novo mutagenesis associated with maternal aging and OS-induced oocyte cohort size. Future research will establish the long-term health consequences of these changes and how these findings will impact the clinical practice and patient counselling in the future.

AB - Children conceived through assisted reproductive technologies (ART) have an elevated risk of lower birthweight, yet the underlying cause remains unclear. Our study explores mitochondrial DNA (mtDNA) variants as contributors to birthweight differences by impacting mitochondrial function during prenatal development. We deep-sequenced the mtDNA of 451 ART and spontaneously conceived (SC) individuals, 157 mother-child pairs and 113 individual oocytes from either natural menstrual cycles or after ovarian stimulation (OS) and find that ART individuals carried a different mtDNA genotype than SC individuals, with more de novo non-synonymous variants. These variants, along with rRNA variants, correlate with lower birthweight percentiles, independent of conception mode. Their higher occurrence in ART individuals stems from de novo mutagenesis associated with maternal aging and OS-induced oocyte cohort size. Future research will establish the long-term health consequences of these changes and how these findings will impact the clinical practice and patient counselling in the future.

UR - http://www.scopus.com/inward/record.url?scp=85184790314&partnerID=8YFLogxK

U2 - 10.1038/s41467-024-45446-1

DO - 10.1038/s41467-024-45446-1

M3 - Article

C2 - 38336715

VL - 15

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1232

ER -

Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

Samenvatting

Bibliografische nota

Toegang tot document

Andere bestanden en links

Vingerafdruk

Projecten

OZRMETH9: De genetische component in infertiliteit en mislukking van vroege menselijke ontwikkeling

FWOTM968: De zoektocht naar de oorsprong van chromosomale afwijkingen in menselijke pre-implantatie-embryo's

FWOSB55: De weg naar een veilige introductie van hESC in de kliniek: de casus van genetisch mozaicisme in hESC-afgeleide retinale cellen

Datasets

Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

Citeer dit