Samenvatting
Objective: To determine the necessity for routinely karyotyping female partners with regular cycles attending a fertility clinic.
Design: Prospective study.
Materials/Methods: A cytogenetic analysis was so far performed in 392 female partners with regular cycles attending our fertility clinic. At least 900 patients are needed to ensure statistical significance. The preliminary results of the ongoing study will be presented.
Results: The average age of the women was 32 years (range 19-46) with an average length of infertility of 3 years 4 months (range 0.5 months to 21 years). Sixty one percent of the couples were primarily infertile and 38.8% were secondarily. This item is unavailable for one patient. A history of previous infertility treatment was found in 33.9% of the couples. The etiology of the infertility was andrological in 192 couples (49%), tubal in 74 couples (18.9%), idiopathic in 86 couples (21.9%) and a result of endometriosis in 32 couples (8.2%). Other causes of infertility were present in 8 couples (2%). In 21 patients (5.4%) no treatment was prescribed. In 99 patients (25.2%) a treatment with timed intercourse or superovulation with or without intra-uterine insemination was proposed. Conventional IVF or ICSI was started in 89 (22.7%) and 172 (43.9%) patients respectively. For 11 patients (2.8%) surgery was proposed. Among the female partners, three abnormal karyotypes were found (0,76%): one 46,XX/46,XY mosaicism, one paracentric inversion (46,X,inv (X) (q13q24)) and one balanced reciprocal translocation (46,XX, t (4;7) (q34;p14)).
Conclusions: So far, the incidence of chromosomal abnormalities among female partners with regular cycles attending a fertility clinic is less than 1%. If these data are confirmed in the larger study population there will be no need for routine karyotyping.
Design: Prospective study.
Materials/Methods: A cytogenetic analysis was so far performed in 392 female partners with regular cycles attending our fertility clinic. At least 900 patients are needed to ensure statistical significance. The preliminary results of the ongoing study will be presented.
Results: The average age of the women was 32 years (range 19-46) with an average length of infertility of 3 years 4 months (range 0.5 months to 21 years). Sixty one percent of the couples were primarily infertile and 38.8% were secondarily. This item is unavailable for one patient. A history of previous infertility treatment was found in 33.9% of the couples. The etiology of the infertility was andrological in 192 couples (49%), tubal in 74 couples (18.9%), idiopathic in 86 couples (21.9%) and a result of endometriosis in 32 couples (8.2%). Other causes of infertility were present in 8 couples (2%). In 21 patients (5.4%) no treatment was prescribed. In 99 patients (25.2%) a treatment with timed intercourse or superovulation with or without intra-uterine insemination was proposed. Conventional IVF or ICSI was started in 89 (22.7%) and 172 (43.9%) patients respectively. For 11 patients (2.8%) surgery was proposed. Among the female partners, three abnormal karyotypes were found (0,76%): one 46,XX/46,XY mosaicism, one paracentric inversion (46,X,inv (X) (q13q24)) and one balanced reciprocal translocation (46,XX, t (4;7) (q34;p14)).
Conclusions: So far, the incidence of chromosomal abnormalities among female partners with regular cycles attending a fertility clinic is less than 1%. If these data are confirmed in the larger study population there will be no need for routine karyotyping.
| Originele taal-2 | English |
|---|---|
| Pagina's (van-tot) | 185 |
| Aantal pagina's | 1 |
| Tijdschrift | Fertil Steril |
| Volume | 76 |
| Nummer van het tijdschrift | September |
| Status | Published - 2001 |
| Evenement | Unknown - Duur: 1 jan 2001 → … |