@article{68357177f3bd48049ff849e5eebba381,
title = "Coingestion of Collagen With Whey Protein Prevents Postexercise Decline in Plasma Glycine Availability in Recreationally Active Men",
abstract = "Whey protein ingestion during recovery from exercise increases myofibrillar but not muscle connective protein synthesis rates. It has been speculated that whey protein does not provide sufficient glycine to maximize postexercise muscle connective protein synthesis rates. In the present study, we assessed the impact of coingesting different amounts of collagen with whey protein as a nutritional strategy to increase plasma glycine availability during recovery from exercise. In a randomized, double-blind, crossover design, 14 recreationally active men (age: 26 ± 5 years; body mass index: 23.8 ± 2.1 kg·m-2) ingested in total 30 g protein, provided as whey protein with 0 g (WHEY), 5 g (WC05); 10 g (WC10), and 15 g (WC15) of collagen protein immediately after a single bout of resistance exercise. Blood samples were collected frequently over 6 hr of postexercise recovery to assess postprandial plasma amino acid kinetics and availability. Protein ingestion strongly increased plasma amino acid concentrations (p < .001) with no differences in plasma total amino acid availability between treatments (p > .05). The postprandial rise in plasma leucine and essential amino acid availability was greater in WHEY compared with the WC10 and WC15 treatments (p < .05). Plasma glycine and nonessential amino acid concentrations declined following whey protein ingestion but increased following collagen coingestion (p < .05). Postprandial plasma glycine availability averaged -8.9 ± 5.8, 9.2 ± 3.7, 23.1 ± 6.5, and 39.8 ± 11.0 mmol·360 min/L in WHEY, WC05, WC10, and WC15, respectively (incremental area under curve values, p < .05). Coingestion of a small amount of collagen (5 g) with whey protein (25 g) is sufficient to prevent the decline in plasma glycine availability during recovery from lower body resistance-type exercise in recreationally active men.",
keywords = "Humans, Whey Proteins/administration & dosage, Male, Collagen, Adult, Glycine/blood, Double-Blind Method, Cross-Over Studies, Young Adult, Postprandial Period, Exercise/physiology, Resistance Training, Sports Nutritional Physiological Phenomena, Amino Acids/blood, Muscle, Skeletal/metabolism",
author = "Thorben Aussieker and Janssen, {Tom A H} and Hermans, {Wesley J H} and Holwerda, {Andrew M} and Senden, {Joan M} and {van Kranenburg}, {Janneau M X} and Goessens, {Joy P B} and Tim Snijders and {van Loon}, {Luc J C}",
note = "Funding Information: The authors thank Floris K. Hendriks for his medical assistance. They also extend their gratitude to all study participants for their time and commitment. Author Contributions: Conceptualization, methodology, and funding acquisition: Aussieker, Snijders, van Loon. Investigation and validation: Aussieker, Janssen, Hermans, Holwerda, Senden, Goessens, van Kranenburg. Formal analysis: Aussieker, Snijders, van Loon. Project administration, visualization, and writing\u2014original draft: Aussieker, Snijders, van Loon. Supervision: Holwerda, Snijders, van Loon. Writing review and editing: Aussieker, Janssen, Hermans, Holwerda, Snijders, van Loon. Read and approved the final manuscript: All authors. This study was funded by a public\u2013private cooperation between Maastricht University, The Netherlands, Gelita AG, Germany, and TKI Health\u223CHolland, The Netherlands. van Loon and his laboratory have received research grants, consulting fees, speaking honoraria, or a combination of these for research on the impact of exercise and nutrition on muscle metabolism, which includes research funding from companies that produce collagen, such as Gelita and PB Leiner. A full overview on research funding is provided at https://www.maastrichtuniversity.nl/l.vanloon. Snijders was supported by a research grant from Gelita AR to perform studies on collagen protein ingestion and postexercise recovery. Aussieker, Janssen, Holwerda, Sen-den, and van Kranenburg report no conflicts of interest related to this work. The authors declare that the results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. This trial was registered at trialregister.nl as NL8748. Publisher Copyright: {\textcopyright} 2024 Human Kinetics Publishers Inc.. All rights reserved.",
year = "2024",
month = jul,
day = "1",
doi = "10.1123/ijsnem.2023-0264",
language = "English",
volume = "34",
pages = "189--198",
journal = "International Journal of Sport Nutrition and Exercise Metabolism",
issn = "1526-484X",
publisher = "Human Kinetics Publishers Inc.",
number = "4",
}