Connexin-based channels in the liver.

Raf Van Campenhout; Kaat Leroy; Axelle Cooreman; Andres Tabernilla Garcia; Bruno Cogliati; Prashant Kadam; Mathieu Vinken

doi:10.1002/cphy.c220007

Connexin-based channels in the liver.

Raf Van Campenhout, Kaat Leroy, Axelle Cooreman, Andres Tabernilla Garcia, Bruno Cogliati, Prashant Kadam, Mathieu Vinken

Onderzoeksoutput: Article › peer review

2 Citaten (Scopus)

166 Downloads (Pure)

Samenvatting

Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell communication by allowing the exchange of small molecules and ions between neighboring cells. In this way, hepatic gap junctions support liver homeostasis. Besides serving as building blocks for gap junctions, connexin hemichannels provide a pathway between the intracellular and the extracellular environment. The activation of connexin hemichannels is associated with acute and chronic liver pathologies. This article discusses the role of gap junctions and connexin hemichannels in the liver.

Originele taal-2	English
Pagina's (van-tot)	4147-4163
Aantal pagina's	17
Tijdschrift	Comprehensive Physiology
Volume	12
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1002/cphy.c220007
Status	Published - jul. 2022

Bibliografische nota

Funding Information:
This work was financially supported by the European Research Council (Proof-of-Concept grant 861913), the European Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders-Belgium (grants G012318N, G020018N, and G0F7219N), the University Hospital of the Vrije Universiteit Brussel-Belgium (Scientific Fund Willy Gepts), the Fundação de Amparo à Pesquisa do Estado de São Paulo-Brazil (FAPESP-FWO grant 18/10953-9). Figures are created with BioRender.

Publisher Copyright:
© American Physiological Society.

Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.

Toegang tot document

10.1002/cphy.c220007

Revised manuscriptAccepted author manuscript, 671 KBLicentie: Unspecified

Andere bestanden en links

Link naar publicatie in Scopus

FWOAL879: 'Nanobody'-gebaseerde inhibitoren van connexine hemikanalen en pannexine kanalen als nieuwe therapeutica voor de behandeling van inflammatoire aandoeningen in de lever en het cardiovasculair systeem.
Vinken, M., Muyldermans, S. & Kwak, B. R.
1/01/18 → 31/12/21
Project: Fundamenteel
FWOAL887: Zijn connexine hemikanalen en pannexine kanalen therapeutische doelwitten en diagnostische biomerkers in cholestase?
Vinken, M. & Annaert, P.
1/01/18 → 31/12/21
Project: Fundamenteel

Citeer dit

@article{e3213ff2a78a4de4a41753e018663625,

title = "Connexin-based channels in the liver.",

abstract = "Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell communication by allowing the exchange of small molecules and ions between neighboring cells. In this way, hepatic gap junctions support liver homeostasis. Besides serving as building blocks for gap junctions, connexin hemichannels provide a pathway between the intracellular and the extracellular environment. The activation of connexin hemichannels is associated with acute and chronic liver pathologies. This article discusses the role of gap junctions and connexin hemichannels in the liver.",

author = "{Van Campenhout}, Raf and Kaat Leroy and Axelle Cooreman and {Tabernilla Garcia}, Andres and Bruno Cogliati and Prashant Kadam and Mathieu Vinken",

note = "Funding Information: This work was financially supported by the European Research Council (Proof-of-Concept grant 861913), the European Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders-Belgium (grants G012318N, G020018N, and G0F7219N), the University Hospital of the Vrije Universiteit Brussel-Belgium (Scientific Fund Willy Gepts), the Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo-Brazil (FAPESP-FWO grant 18/10953-9). Figures are created with BioRender. Publisher Copyright: {\textcopyright} American Physiological Society. Copyright: Copyright 2022 Elsevier B.V., All rights reserved.",

year = "2022",

month = jul,

doi = "10.1002/cphy.c220007",

language = "English",

volume = "12",

pages = "4147--4163",

journal = "Comprehensive Physiology",

issn = "2040-4603",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Connexin-based channels in the liver.

AU - Van Campenhout, Raf

AU - Leroy, Kaat

AU - Cooreman, Axelle

AU - Tabernilla Garcia, Andres

AU - Cogliati, Bruno

AU - Kadam, Prashant

AU - Vinken, Mathieu

N1 - Funding Information: This work was financially supported by the European Research Council (Proof-of-Concept grant 861913), the European Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders-Belgium (grants G012318N, G020018N, and G0F7219N), the University Hospital of the Vrije Universiteit Brussel-Belgium (Scientific Fund Willy Gepts), the Fundação de Amparo à Pesquisa do Estado de São Paulo-Brazil (FAPESP-FWO grant 18/10953-9). Figures are created with BioRender. Publisher Copyright: © American Physiological Society. Copyright: Copyright 2022 Elsevier B.V., All rights reserved.

PY - 2022/7

Y1 - 2022/7

N2 - Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell communication by allowing the exchange of small molecules and ions between neighboring cells. In this way, hepatic gap junctions support liver homeostasis. Besides serving as building blocks for gap junctions, connexin hemichannels provide a pathway between the intracellular and the extracellular environment. The activation of connexin hemichannels is associated with acute and chronic liver pathologies. This article discusses the role of gap junctions and connexin hemichannels in the liver.

AB - Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell communication by allowing the exchange of small molecules and ions between neighboring cells. In this way, hepatic gap junctions support liver homeostasis. Besides serving as building blocks for gap junctions, connexin hemichannels provide a pathway between the intracellular and the extracellular environment. The activation of connexin hemichannels is associated with acute and chronic liver pathologies. This article discusses the role of gap junctions and connexin hemichannels in the liver.

UR - http://www.scopus.com/inward/record.url?scp=85136290262&partnerID=8YFLogxK

U2 - 10.1002/cphy.c220007

DO - 10.1002/cphy.c220007

M3 - Article

SN - 2040-4603

VL - 12

SP - 4147

EP - 4163

JO - Comprehensive Physiology

JF - Comprehensive Physiology

IS - 4

ER -

Connexin-based channels in the liver.

Samenvatting

Bibliografische nota

Toegang tot document

Andere bestanden en links

Vingerafdruk

Projecten

FWOAL879: 'Nanobody'-gebaseerde inhibitoren van connexine hemikanalen en pannexine kanalen als nieuwe therapeutica voor de behandeling van inflammatoire aandoeningen in de lever en het cardiovasculair systeem.

FWOAL887: Zijn connexine hemikanalen en pannexine kanalen therapeutische doelwitten en diagnostische biomerkers in cholestase?

Citeer dit