Connexins, pannexins and their channels in fibroproliferative diseases

Bruno Cogliati, Gregory Mennecier, Joost Willebrords, Tereza Cristina da Silva, Michaël Maes, Isabel Veloso Alves Pereira, Sara Crespo Yanguas, Francisco Hernandez-Blazquez, Maria Lucia Zaidan Dagli, Mathieu Vinken

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17 Citaten (Scopus)

Samenvatting

Cellular and molecular mechanisms of wound healing, tissue repair and fibrogenesis are established in different organs and are essential for the maintenance of function and tissue integrity after cell injury. These mechanisms are also involved in a plethora of fibroproliferative diseases or organ-specific fibrotic disorders, all of which are associated with the excessive deposition of extracellular matrix components. Fibroblasts, which are key cells in tissue repair and fibrogenesis, rely on communicative cellular networks to ensure efficient control of these processes and to prevent abnormal accumulation of extracellular matrix into the tissue. Despite the significant impact on human health, and thus the epidemiologic relevance, there is still no effective treatment for most fibrosis-related diseases. This paper provides an overview of current concepts and mechanisms involved in the participation of cellular communication via connexin-based pores as well as pannexin-based channels in the processes of tissue repair and fibrogenesis in chronic diseases. Understanding these mechanisms may contribute to the development of new therapeutic strategies to clinically manage fibroproliferative diseases and organ-specific fibrotic disorders.
Originele taal-2English
Pagina's (van-tot)199-213
TijdschriftJournal of Membrane Biology
Volume249
Nummer van het tijdschrift3
Vroegere onlinedatum15 feb 2016
DOI's
StatusPublished - 23 mei 2016

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    Crespo Yanguas, S., Willebrords, J., Maes, M., da Silva, T. C., Alves Pereira, I. V., Cogliati, B., Zaidan Dagli, M. L. & Vinken, M., 18 feb 2016, In: EXCLI Journal. 15, blz. 177-186 10 blz.

    Onderzoeksoutput: Articlepeer review

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