Projecten per jaar
Samenvatting
Cellular and molecular mechanisms of wound healing, tissue repair and fibrogenesis are established in different organs and are essential for the maintenance of function and tissue integrity after cell injury. These mechanisms are also involved in a plethora of fibroproliferative diseases or organ-specific fibrotic disorders, all of which are associated with the excessive deposition of extracellular matrix components. Fibroblasts, which are key cells in tissue repair and fibrogenesis, rely on communicative cellular networks to ensure efficient control of these processes and to prevent abnormal accumulation of extracellular matrix into the tissue. Despite the significant impact on human health, and thus the epidemiologic relevance, there is still no effective treatment for most fibrosis-related diseases. This paper provides an overview of current concepts and mechanisms involved in the participation of cellular communication via connexin-based pores as well as pannexin-based channels in the processes of tissue repair and fibrogenesis in chronic diseases. Understanding these mechanisms may contribute to the development of new therapeutic strategies to clinically manage fibroproliferative diseases and organ-specific fibrotic disorders.
Originele taal-2 | English |
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Pagina's (van-tot) | 199-213 |
Tijdschrift | Journal of Membrane Biology |
Volume | 249 |
Nummer van het tijdschrift | 3 |
Vroegere onlinedatum | 15 feb 2016 |
DOI's | |
Status | Published - 23 mei 2016 |
Vingerafdruk
Duik in de onderzoeksthema's van 'Connexins, pannexins and their channels in fibroproliferative diseases'. Samen vormen ze een unieke vingerafdruk.-
OZR2651: Internationale alliantie-onderzoeksgroep: hepatische connexines en pannexines
Vinken, M., Rogiers, V., Cogliati, B. & Dagli, M. L.
1/08/14 → 1/07/26
Project: Fundamenteel
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OZR2813: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject: Bench Fee voor Joint PhD VUB-Universidade de Sao Paulo, Michael Maes
10/06/15 → 31/07/17
Project: Fundamenteel
Onderzoekersoutput
- 17 Citaties
- 1 Article
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Connexins and pannexins in liver damage
Crespo Yanguas, S., Willebrords, J., Maes, M., da Silva, T. C., Alves Pereira, I. V., Cogliati, B., Zaidan Dagli, M. L. & Vinken, M., 18 feb 2016, In: EXCLI Journal. 15, blz. 177-186 10 blz.Onderzoeksoutput: Article › peer review
Activiteiten
- 2 Talk or presentation at a workshop/seminar
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The role of connexins, pannexins and their channels in liver fibrosis
Sara Crespo Yanguas (Speaker)
28 nov 2018Activiteit: Talk or presentation at a workshop/seminar
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In vitro characterization of connexin and pannexin (hemi)channel inhibitors:target selectivity and anti-fibrotic efficacy
Sara Crespo Yanguas (Speaker)
14 apr 2015Activiteit: Talk or presentation at a workshop/seminar