Corticosteroids in the management of acute multiple sclerosis exacerbations

I Smets, L Van Deun, C Bohyn, V van Pesch, L Vanopdenbosch, D Dive, V Bissay, B Dubois, Belgian Study Group for Multiple Sclerosis

Onderzoeksoutput: Article

14 Citaten (Scopus)


Multiple sclerosis (MS) is an autoimmune, inflammatory demyelinating disease of the central nervous system characterized in the majority of the patients by a relapsing-remitting disease course. For decades high-dosage corticosteroids (CS) are considered the cornerstone in the management of acute MS relapses. However, many unanswered questions remain when it comes to the exact modalities of CS administration. In this review on behalf of the Belgian Study Group for MS we define the efficacy of CS in reducing MS-related morbidity and examine whether the effect is different according to type of CS, route of administration, cumulative dosage, timing of initiation and disease course. We also review the use of CS in combination with other MS treatments and during pregnancy and lactation. Furthermore, we delineate the relevant adverse events due to a pulse CS regimen and present a decision tree that can be used when treating MS relapses in clinical practice.

Originele taal-2English
Pagina's (van-tot)623-633
Aantal pagina's11
TijdschriftActa Neurologica Belgica
Nummer van het tijdschrift3
Vroegere onlinedatum8 apr 2017
StatusPublished - sep 2017


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