TY - JOUR
T1 - Detection and Scoring of Extracorporeal Circuit Clotting During Hemodialysis
AU - Vanommeslaeghe, Floris
AU - Van Biesen, Wim
AU - François, Karlien
N1 - Funding Information:
Conflict of interest statement: Wim van Biesen received investigator-initiated research grants and speaker fees from Baxter, Nipro, and Fresenius. Karlien François received investigator-initiated research grants from Baxter and Fresenius; speaker fees from Baxter, Fresenius, and AstraZeneca; and consultancy fees from Hemotech Belux.
Funding Information:
Financial support: none. Conflict of interest statement: Wim van Biesen received investigator-initiated research grants and speaker fees from Baxter, Nipro, and Fresenius. Karlien François received investigator-initiated research grants from Baxter and Fresenius; speaker fees from Baxter, Fresenius, and AstraZeneca; and consultancy fees from Hemotech Belux.
Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2024/1/23
Y1 - 2024/1/23
N2 - Maintaining patency of the extracorporeal hemodialysis (HD) circuit is a prerequisite to perform HD. Unfractionated heparin and low-molecular-weight heparins are the most used anticoagulants in maintenance HD, but their administration comes with a major trade-off of bleeding complications. This narrative review article discusses technical factors impacting on HD circuit patency, such as tubings, dialyzer membranes, priming practices, and treatment settings. Strategies for monitoring extracorporeal circuit clotting during and after treatment are also reviewed, as these are essential tools for optimizing anticoagulation.
AB - Maintaining patency of the extracorporeal hemodialysis (HD) circuit is a prerequisite to perform HD. Unfractionated heparin and low-molecular-weight heparins are the most used anticoagulants in maintenance HD, but their administration comes with a major trade-off of bleeding complications. This narrative review article discusses technical factors impacting on HD circuit patency, such as tubings, dialyzer membranes, priming practices, and treatment settings. Strategies for monitoring extracorporeal circuit clotting during and after treatment are also reviewed, as these are essential tools for optimizing anticoagulation.
KW - clotting
KW - Hemodialysis
KW - micro-CT
KW - thrombin
UR - http://www.scopus.com/inward/record.url?scp=85182370561&partnerID=8YFLogxK
U2 - 10.1016/j.semnephrol.2023.151474
DO - 10.1016/j.semnephrol.2023.151474
M3 - Scientific review
C2 - 38267348
AN - SCOPUS:85182370561
SN - 0270-9295
VL - 1
JO - Seminars in Nephrology
JF - Seminars in Nephrology
IS - 1
M1 - 151474
ER -