Samenvatting
OBJECTIVE: To test the developmental competence of oocytes in a nonhCG-triggered in vitro maturation (IVM) system when oocyte-cumulus complexes (OCC) are retrieved from antral follicles with a diameter of
DESIGN: Prospective cohort study.
SETTING: Tertiary university-based referral center.
PATIENT(S): From January 2010 to September 2011, 121 patients with polycystic ovaries/polycystic ovary syndrome underwent 239 IVM cycles in total. In 58 of these cycles (44 patients), all antral follicles had a diameter of
INTERVENTION(S): NonhCG-triggered IVM of oocytes, fresh or vitrified/warmed embryo transfer (ET).
MAIN OUTCOME MEASURE(S): Oocyte diameter, maturation rate, fertilization rate, embryo development and morphology, implantation rate, clinical pregnancy rate, ongoing pregnancy rate.
RESULT(S): Oocyte retrieval yielded 16.7 OCC/cycle, and 50.8% of oocytes completed IVM. The mean oocyte diameter increased from 108.8 ± 4.3 µm to 111.9 ± 4.1 µm after IVM. Mean fertilization rate was 63.7%, and 45.4% of 2-pronuclei oocytes developed into a morphologically good-quality embryo on day 3 after intracytoplasmic sperm injection. Fresh ET resulted in two ongoing pregnancies (2/37; 5.4%). Deferred vitrified-warmed ET led to an ongoing pregnancy rate of 34.6% (9/24). Three healthy babies were born and eight pregnancies were still ongoing.
CONCLUSION(S): Oocytes retrieved from follicles with a diameter of
DESIGN: Prospective cohort study.
SETTING: Tertiary university-based referral center.
PATIENT(S): From January 2010 to September 2011, 121 patients with polycystic ovaries/polycystic ovary syndrome underwent 239 IVM cycles in total. In 58 of these cycles (44 patients), all antral follicles had a diameter of
INTERVENTION(S): NonhCG-triggered IVM of oocytes, fresh or vitrified/warmed embryo transfer (ET).
MAIN OUTCOME MEASURE(S): Oocyte diameter, maturation rate, fertilization rate, embryo development and morphology, implantation rate, clinical pregnancy rate, ongoing pregnancy rate.
RESULT(S): Oocyte retrieval yielded 16.7 OCC/cycle, and 50.8% of oocytes completed IVM. The mean oocyte diameter increased from 108.8 ± 4.3 µm to 111.9 ± 4.1 µm after IVM. Mean fertilization rate was 63.7%, and 45.4% of 2-pronuclei oocytes developed into a morphologically good-quality embryo on day 3 after intracytoplasmic sperm injection. Fresh ET resulted in two ongoing pregnancies (2/37; 5.4%). Deferred vitrified-warmed ET led to an ongoing pregnancy rate of 34.6% (9/24). Three healthy babies were born and eight pregnancies were still ongoing.
CONCLUSION(S): Oocytes retrieved from follicles with a diameter of
| Originele taal-2 | English |
|---|---|
| Pagina's (van-tot) | 503-507 |
| Aantal pagina's | 5 |
| Tijdschrift | Fertility and Sterility |
| Volume | 98 |
| Status | Published - 2012 |