Different cardiovascular risk factors are related to distinct white matter hyperintensity MRI phenotypes in older adults

Jasmin A Keller, Ilse M J Kant, Arjen J C Slooter, Simone J T van Montfort, Mark A van Buchem, Matthias J P van Osch, Jeroen Hendrikse, Jeroen de Bresser

Onderzoeksoutput: Articlepeer review

3 Citaten (Scopus)

Samenvatting

The underlying mechanisms of the association between cardiovascular risk factors and a higher white matter hyperintensity (WMH) burden are unknown. We investigated the association between cardiovascular risk factors and advanced WMH markers in 155 non-demented older adults (mean age: 71 ± 5 years). The association between cardiovascular risk factors and quantitative MRI-based WMH shape and volume markers were examined using linear regression analysis. Presence of hypertension was associated with a more irregular shape of periventricular/confluent WMH (convexity (B (95 % CI)): -0.12 (-0.22--0.03); concavity index: 0.06 (0.02-0.11)), but not with total WMH volume (0.22 (-0.15-0.59)). Presence of diabetes was associated with deep WMH volume (0.89 (0.15-1.63)). Body mass index or hyperlipidemia showed no association with WMH markers. In conclusion, different cardiovascular risk factors seem to be related to a distinct pattern of WMH shape markers in non-demented older adults. These findings may suggest that different underlying cardiovascular pathological mechanisms lead to different WMH MRI phenotypes, which may be valuable for early detection of individuals at risk for stroke and dementia.

Originele taal-2English
Artikelnummer103131
Pagina's (van-tot)103-131
Aantal pagina's29
TijdschriftNeuroImage: Clinical
Volume35
DOI's
StatusPublished - jan 2022

Bibliografische nota

Funding Information:
The research of Jeroen de Bresser was funded by an Alzheimer Nederland grant (WE.03-2019-08).

Publisher Copyright:
© 2022 The Author(s)

Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.

Vingerafdruk

Duik in de onderzoeksthema's van 'Different cardiovascular risk factors are related to distinct white matter hyperintensity MRI phenotypes in older adults'. Samen vormen ze een unieke vingerafdruk.

Citeer dit