TY - JOUR
T1 - Diphtheria in Belgium
T2 - 2010-2017
AU - Martini, Helena
AU - Soetens, Oriane
AU - Litt, David
AU - Fry, Norman K
AU - Detemmerman, Liselot
AU - Wybo, Ingrid
AU - Desombere, Isabelle
AU - Efstratiou, Androulla
AU - Piérard, Denis
PY - 2019
Y1 - 2019
N2 - In Western Europe, the incidence of both respiratory and cutaneous diphtheria, caused by toxin-producing Corynebacterium diphtheriae, Corynebacterium ulcerans or Corynebacterium pseudotuberculosis, has been low over the past few decades thanks to the use of an effective vaccine and a high level of vaccination coverage. However, the disease has still not been eradicated and continues to occur in all of Europe. In order to prevent sequelae or a fatal outcome, diphtheria antitoxin (DAT) should be administered to suspected diphtheria patients as soon as possible, but economic factors and issues concerning regulations have led to poor availability of DAT in many countries. The European Centre for Disease Prevention and Control and World Health Organization have called for European Union-wide solutions to this DAT-shortage. In order to illustrate the importance of these efforts and underline the need for continued diphtheria surveillance, we present data on all registered cases of toxigenic and non-toxigenic C. diphtheriae, C. ulcerans and C. pseudotuberculosis in Belgium during the past decade, up to and including 2017.
AB - In Western Europe, the incidence of both respiratory and cutaneous diphtheria, caused by toxin-producing Corynebacterium diphtheriae, Corynebacterium ulcerans or Corynebacterium pseudotuberculosis, has been low over the past few decades thanks to the use of an effective vaccine and a high level of vaccination coverage. However, the disease has still not been eradicated and continues to occur in all of Europe. In order to prevent sequelae or a fatal outcome, diphtheria antitoxin (DAT) should be administered to suspected diphtheria patients as soon as possible, but economic factors and issues concerning regulations have led to poor availability of DAT in many countries. The European Centre for Disease Prevention and Control and World Health Organization have called for European Union-wide solutions to this DAT-shortage. In order to illustrate the importance of these efforts and underline the need for continued diphtheria surveillance, we present data on all registered cases of toxigenic and non-toxigenic C. diphtheriae, C. ulcerans and C. pseudotuberculosis in Belgium during the past decade, up to and including 2017.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Anti-Bacterial Agents/pharmacology
KW - Belgium/epidemiology
KW - Child, Preschool
KW - Corynebacterium/classification
KW - Diphtheria/epidemiology
KW - Diphtheria Toxin/genetics
KW - Drug Resistance, Bacterial
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
UR - http://www.scopus.com/inward/record.url?scp=85072945119&partnerID=8YFLogxK
U2 - 10.1099/jmm.0.001039
DO - 10.1099/jmm.0.001039
M3 - Article
C2 - 31418673
VL - 68
SP - 1517
EP - 1525
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
SN - 0022-2615
IS - 10
ER -