Samenvatting

Introduction:
Shoulder/arm morbidity is a common complication of breast cancer surgery and radiotherapy (RT), but little is known
about acute contralateral morbidity.
Methods:
Patients were 118 women enrolled in a RT trial. Arm volume and shoulder mobility were assessed before and 1-3 months
after RT. Correlations and linear regression were used to analyze changes affecting ipsilateral and contralateral arms, and changes affecting
relative interlimb differences (RID).
Results:
Changes affecting one limb correlated with changes affecting the other limb. Arm volume between the two limbs correlated
(R = 0.57). Risk factors were weight increase and axillary dissection. Contralateral and ipsilateral loss of abduction strongly correlated
(R = 0.78). Changes of combined RID exceeding 10% affected the ipsilateral limb in 25% of patients, and the contralateral limb in 18%.
Aromatase inhibitor therapy was significantly associated with contralateral loss of abduction.
Conclusions:
High incidence of early contralateral arm morbidity warrants further investigations.
Originele taal-2English
Pagina's (van-tot)79-93
Aantal pagina's15
TijdschriftBreast Cancer: Basic and Clinical Research
Volume6
DOI's
StatusPublished - 2012

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