Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

Toshimitsu Tsugu; Adriana Postolache; Raluca Dulgheru; Tadafumi Sugimoto; Julien Tridetti; Mai-Linh Nguyen Trung; Caroline Piette; Marie Moonen; Roberta Manganaro; Federica Ilardi; Alexandra Maria Chitroceanu; Simona Sperlongano; Yun Yun Go; George Kacharava; George D Athanassopoulos; Daniele Barone; Monica Baroni; Nuno Cardim; Andreas Hagendorff; Krasimira Hristova; Teresa Lopez; Gonzalo de la Morena; Bogdan A Popescu; Martin Penicka; Tolga Ozyigit; Jose David Rodrigo Carbonero; Nico van de Veire; Ralph Stephan Von Bardeleben; Dragos Vinereanu; Jose Luis Zamorano; Monica Rosca; Andreea Calin; Julien Magne; Bernard Cosyns; Elena Galli; Erwan Donal; Ciro Santoro; Maurizio Galderisi; Luigi P Badano; Roberto M Lang; Patrizio Lancellotti

doi:10.1093/ehjci/jeaa050

Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

Toshimitsu Tsugu, Adriana Postolache, Raluca Dulgheru, Tadafumi Sugimoto, Julien Tridetti, Mai-Linh Nguyen Trung, Caroline Piette, Marie Moonen, Roberta Manganaro, Federica Ilardi, Alexandra Maria Chitroceanu, Simona Sperlongano, Yun Yun Go, George Kacharava, George D Athanassopoulos, Daniele Barone, Monica Baroni, Nuno Cardim, Andreas Hagendorff, Krasimira HristovaTeresa Lopez, Gonzalo de la Morena, Bogdan A Popescu, Martin Penicka, Tolga Ozyigit, Jose David Rodrigo Carbonero, Nico van de Veire, Ralph Stephan Von Bardeleben, Dragos Vinereanu, Jose Luis Zamorano, Monica Rosca, Andreea Calin, Julien Magne, Bernard Cosyns, Elena Galli, Erwan Donal, Ciro Santoro, Maurizio Galderisi, Luigi P Badano, Roberto M Lang, Patrizio Lancellotti

Onderzoeksoutput: Article › peer review

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AIMS : To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages.

METHODS AND RESULTS : A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were -15.0% in men and -15.6% in women for epicardial strain, -16.8% and -17.7% for mid-myocardial strain, and -18.7% and -19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = -0.20, P = 0.007, mid-myocardial; r = -0.21, P = 0.006, endocardial; r = -0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1).

CONCLUSION : The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.

Originele taal-2	English
Pagina's (van-tot)	896-905
Aantal pagina's	10
Tijdschrift	European heart journal cardiovascular Imaging
Volume	21
Nummer van het tijdschrift	8
DOI's	https://doi.org/10.1093/ehjci/jeaa050
Status	Published - 1 aug. 2020

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Tsugu, T., Postolache, A., Dulgheru, R., Sugimoto, T., Tridetti, J., Nguyen Trung, M.-L., Piette, C., Moonen, M., Manganaro, R., Ilardi, F., Chitroceanu, A. M., Sperlongano, S., Go, Y. Y., Kacharava, G., Athanassopoulos, G. D., Barone, D., Baroni, M., Cardim, N., Hagendorff, A., ... Lancellotti, P. (2020). Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study. European heart journal cardiovascular Imaging, 21(8), 896-905. https://doi.org/10.1093/ehjci/jeaa050

@article{0a30252ec3c4455a8b33ebf7bf9c92f4,

title = "Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study",

abstract = "AIMS : To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages.METHODS AND RESULTS : A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were -15.0% in men and -15.6% in women for epicardial strain, -16.8% and -17.7% for mid-myocardial strain, and -18.7% and -19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = -0.20, P = 0.007, mid-myocardial; r = -0.21, P = 0.006, endocardial; r = -0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1).CONCLUSION : The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.",

keywords = "2D echocardiography, adult echocardiography, deformation imaging, reference values.",

author = "Toshimitsu Tsugu and Adriana Postolache and Raluca Dulgheru and Tadafumi Sugimoto and Julien Tridetti and {Nguyen Trung}, Mai-Linh and Caroline Piette and Marie Moonen and Roberta Manganaro and Federica Ilardi and Chitroceanu, {Alexandra Maria} and Simona Sperlongano and Go, {Yun Yun} and George Kacharava and Athanassopoulos, {George D} and Daniele Barone and Monica Baroni and Nuno Cardim and Andreas Hagendorff and Krasimira Hristova and Teresa Lopez and {de la Morena}, Gonzalo and Popescu, {Bogdan A} and Martin Penicka and Tolga Ozyigit and {Rodrigo Carbonero}, {Jose David} and {van de Veire}, Nico and {Von Bardeleben}, {Ralph Stephan} and Dragos Vinereanu and Zamorano, {Jose Luis} and Monica Rosca and Andreea Calin and Julien Magne and Bernard Cosyns and Elena Galli and Erwan Donal and Ciro Santoro and Maurizio Galderisi and Badano, {Luigi P} and Lang, {Roberto M} and Patrizio Lancellotti",

year = "2020",

month = aug,

day = "1",

doi = "10.1093/ehjci/jeaa050",

language = "English",

volume = "21",

pages = "896--905",

journal = "European heart journal cardiovascular Imaging",

issn = "2047-2404",

publisher = "Oxford University Press",

number = "8",

}

Tsugu, T, Postolache, A, Dulgheru, R, Sugimoto, T, Tridetti, J, Nguyen Trung, M-L, Piette, C, Moonen, M, Manganaro, R, Ilardi, F, Chitroceanu, AM, Sperlongano, S, Go, YY, Kacharava, G, Athanassopoulos, GD, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez, T, de la Morena, G, Popescu, BA, Penicka, M, Ozyigit, T, Rodrigo Carbonero, JD, van de Veire, N, Von Bardeleben, RS, Vinereanu, D, Zamorano, JL, Rosca, M, Calin, A, Magne, J , Cosyns, B, Galli, E, Donal, E, Santoro, C, Galderisi, M, Badano, LP, Lang, RM & Lancellotti, P 2020, 'Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study', European heart journal cardiovascular Imaging, vol. 21, nr. 8, blz. 896-905. https://doi.org/10.1093/ehjci/jeaa050

TY - JOUR

T1 - Echocardiographic reference ranges for normal left ventricular layer-specific strain

T2 - results from the EACVI NORRE study

AU - Tsugu, Toshimitsu

AU - Postolache, Adriana

AU - Dulgheru, Raluca

AU - Sugimoto, Tadafumi

AU - Tridetti, Julien

AU - Nguyen Trung, Mai-Linh

AU - Piette, Caroline

AU - Moonen, Marie

AU - Manganaro, Roberta

AU - Ilardi, Federica

AU - Chitroceanu, Alexandra Maria

AU - Sperlongano, Simona

AU - Go, Yun Yun

AU - Kacharava, George

AU - Athanassopoulos, George D

AU - Barone, Daniele

AU - Baroni, Monica

AU - Cardim, Nuno

AU - Hagendorff, Andreas

AU - Hristova, Krasimira

AU - Lopez, Teresa

AU - de la Morena, Gonzalo

AU - Popescu, Bogdan A

AU - Penicka, Martin

AU - Ozyigit, Tolga

AU - Rodrigo Carbonero, Jose David

AU - van de Veire, Nico

AU - Von Bardeleben, Ralph Stephan

AU - Vinereanu, Dragos

AU - Zamorano, Jose Luis

AU - Rosca, Monica

AU - Calin, Andreea

AU - Magne, Julien

AU - Cosyns, Bernard

AU - Galli, Elena

AU - Donal, Erwan

AU - Santoro, Ciro

AU - Galderisi, Maurizio

AU - Badano, Luigi P

AU - Lang, Roberto M

AU - Lancellotti, Patrizio

PY - 2020/8/1

Y1 - 2020/8/1

N2 - AIMS : To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages.METHODS AND RESULTS : A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were -15.0% in men and -15.6% in women for epicardial strain, -16.8% and -17.7% for mid-myocardial strain, and -18.7% and -19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = -0.20, P = 0.007, mid-myocardial; r = -0.21, P = 0.006, endocardial; r = -0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1).CONCLUSION : The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.

AB - AIMS : To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages.METHODS AND RESULTS : A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were -15.0% in men and -15.6% in women for epicardial strain, -16.8% and -17.7% for mid-myocardial strain, and -18.7% and -19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = -0.20, P = 0.007, mid-myocardial; r = -0.21, P = 0.006, endocardial; r = -0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1).CONCLUSION : The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.

KW - 2D echocardiography

KW - adult echocardiography

KW - deformation imaging

KW - reference values.

UR - http://www.scopus.com/inward/record.url?scp=85088494543&partnerID=8YFLogxK

U2 - 10.1093/ehjci/jeaa050

DO - 10.1093/ehjci/jeaa050

M3 - Article

C2 - 32259844

SN - 2047-2404

VL - 21

SP - 896

EP - 905

JO - European heart journal cardiovascular Imaging

JF - European heart journal cardiovascular Imaging

IS - 8

ER -

Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study

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