Effect of an acute d-amphetamine administration on context information memory in healthy volunteers: Evidence from a source memory task.

Inge Zeeuws; Natacha Deroost; Eric Soetens

doi:https://doi.org/10.1002/hup.1120

Invloed van d-amfetamine op het menselijke lange-termijn geheugen

Inge Zeeuws, Natacha Deroost, Eric Soetens

Onderzoeksoutput: Article › peer review

15 Citaten (Scopus)

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Onderzoek naar de invloed van d-amfetamine op het menselijke lange-termijn geheugen. Er werd een positieve invloed gevonden van d-amfetamine op zowel item- als contextgeheugen.

Vertaalde titel van de bijdrage	Invloed van d-amfetamine op het menselijke lange-termijn geheugen
Originele taal-2	English
Pagina's (van-tot)	326-344
Aantal pagina's	19
Tijdschrift	Human Psychopharmacology: Clinical and Experimental
Volume	25
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1002/hup.1120
Status	Published - 1 jul 2010

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https://doi.org/10.1002/hup.1120

OZR1389: Geheugenconsolidatie van verbaal en niet-verbaal stimulusmateriaal bij expliciet leren en impliciet leren.
Soetens, E.
1/01/07 → 31/12/07
Project: Fundamenteel
OZR825: Geheugenconsolidatie van verbaal en niet-verbaal stimulusmateriaal bij expliciet en impliciet leren
Soetens, E., Deroost, N. & Zeeuws, I.
1/01/03 → 31/12/06
Project: Fundamenteel
1971141650: Menselijke geheugen consolidatie onderzocht met amfetamine (verlenging)
Soetens, E.
1/01/97 → 31/12/97
Project: Fundamenteel

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@article{07f9b2aca6cc49d3baa673be6ff5bcd6,

title = "Effect of an acute d-amphetamine administration on context information memory in healthy volunteers: Evidence from a source memory task.",

abstract = "Rationale: Previous research demonstrated a positive effect of d-amphetamine on long-term verbal memory. An improvement in memory for contextual information is proposed as a possible mechanism underlying the d-amphetamine facilitation effect. Objectives: A double blind, placebo controlled experiment was used to examine the processes involved in episodic memory affected by an acute administration of d-amphetamine. We investigated whether positive effects of d-amphetamine on item memory could be extended to context information by using a source memory paradigm. Methods: In a within-subjects design with two sessions, two study lists were presented in each session and participants were required to make an old/new recognition decision (item memory) and a list discrimination judgement (source memory) after delays of one hour, one day, and one week. Results: Enhancement of item memory after d-amphetamine intake was observed on delayed tests only, confirming that amphetamine does not affect short-term memory or memory acquisition, but rather a process operating after initial encoding. Importantly, we found an enhancement in remembering the source of recognized items after d-amphetamine administration. Conclusion: The present study suggests that an acute administration of d-amphetamine helps to bind different features of an item in memory, in turn leading to an increased ability to recollect both the item and its context.",

keywords = "d-amphetamine, human memory, consolidation, context information",

author = "Inge Zeeuws and Natacha Deroost and Eric Soetens",

year = "2010",

month = jul,

day = "1",

doi = "https://doi.org/10.1002/hup.1120",

language = "English",

volume = "25",

pages = "326--344",

journal = "Human Psychopharmacology: Clinical and Experimental",

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TY - JOUR

T1 - Effect of an acute d-amphetamine administration on context information memory in healthy volunteers: Evidence from a source memory task.

AU - Zeeuws, Inge

AU - Deroost, Natacha

AU - Soetens, Eric

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Rationale: Previous research demonstrated a positive effect of d-amphetamine on long-term verbal memory. An improvement in memory for contextual information is proposed as a possible mechanism underlying the d-amphetamine facilitation effect. Objectives: A double blind, placebo controlled experiment was used to examine the processes involved in episodic memory affected by an acute administration of d-amphetamine. We investigated whether positive effects of d-amphetamine on item memory could be extended to context information by using a source memory paradigm. Methods: In a within-subjects design with two sessions, two study lists were presented in each session and participants were required to make an old/new recognition decision (item memory) and a list discrimination judgement (source memory) after delays of one hour, one day, and one week. Results: Enhancement of item memory after d-amphetamine intake was observed on delayed tests only, confirming that amphetamine does not affect short-term memory or memory acquisition, but rather a process operating after initial encoding. Importantly, we found an enhancement in remembering the source of recognized items after d-amphetamine administration. Conclusion: The present study suggests that an acute administration of d-amphetamine helps to bind different features of an item in memory, in turn leading to an increased ability to recollect both the item and its context.

AB - Rationale: Previous research demonstrated a positive effect of d-amphetamine on long-term verbal memory. An improvement in memory for contextual information is proposed as a possible mechanism underlying the d-amphetamine facilitation effect. Objectives: A double blind, placebo controlled experiment was used to examine the processes involved in episodic memory affected by an acute administration of d-amphetamine. We investigated whether positive effects of d-amphetamine on item memory could be extended to context information by using a source memory paradigm. Methods: In a within-subjects design with two sessions, two study lists were presented in each session and participants were required to make an old/new recognition decision (item memory) and a list discrimination judgement (source memory) after delays of one hour, one day, and one week. Results: Enhancement of item memory after d-amphetamine intake was observed on delayed tests only, confirming that amphetamine does not affect short-term memory or memory acquisition, but rather a process operating after initial encoding. Importantly, we found an enhancement in remembering the source of recognized items after d-amphetamine administration. Conclusion: The present study suggests that an acute administration of d-amphetamine helps to bind different features of an item in memory, in turn leading to an increased ability to recollect both the item and its context.

KW - d-amphetamine

KW - human memory

KW - consolidation

KW - context information

U2 - https://doi.org/10.1002/hup.1120

DO - https://doi.org/10.1002/hup.1120

M3 - Article

VL - 25

SP - 326

EP - 344

JO - Human Psychopharmacology: Clinical and Experimental

JF - Human Psychopharmacology: Clinical and Experimental

SN - 0885-6222

IS - 4

ER -

Invloed van d-amfetamine op het menselijke lange-termijn geheugen

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Projecten

OZR1389: Geheugenconsolidatie van verbaal en niet-verbaal stimulusmateriaal bij expliciet leren en impliciet leren.

OZR825: Geheugenconsolidatie van verbaal en niet-verbaal stimulusmateriaal bij expliciet en impliciet leren

1971141650: Menselijke geheugen consolidatie onderzocht met amfetamine (verlenging)

Citeer dit