Effect of periodontal disease treatment during pregnancy on preterm birth incidence: a metaanalysis of randomized trials

Nikolaos P Polyzos, Ilias P Polyzos, Davide Mauri, Spyridon Tzioras, Maria Tsappi, Ivan Cortinovis, Giovanni Casazza

Onderzoeksoutput: Articlepeer review

97 Citaten (Scopus)

Samenvatting

We conducted a metaanalysis of randomized controlled trials to determine whether periodontal disease treatment with scaling and/or root planing during pregnancy may reduce preterm birth (PTB) or low birthweight (LBW) infant incidence. Treatment resulted in significantly lower PTB (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.35-0.86; P = .008) and borderline significantly lower LBW (OR, 0.48; 95% CI, 0.23-1.00; P = .049), whereas no difference was found for spontaneous abortion/stillbirth (OR, 0.73; 95% CI, 0.41-1.31; P = .292). Subgroup analysis suggested significant effect of treatment in the absence of history of PTB or LBW (OR, 0.48; 95% CI, 0.29-0.77; P = .003) and less severe periodontal disease as defined by probing depth (OR, 0.49; 95% CI, 0.28-0.87; P = .014) or bleeding on probing site (OR, 0.37; 95% CI, 0.14-0.95; P = .04). If ongoing large and well-designed randomized trials support our results, we might need to reassess current practice or at least be cautious prior to rejecting treatment of periodontal disease with scaling and/or root planing during pregnancy.

Originele taal-2English
Pagina's (van-tot)225-232
Aantal pagina's8
TijdschriftAmerican Journal of Obstetrics & Gynecology
Volume200
Nummer van het tijdschrift3
DOI's
StatusPublished - 2009

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