Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy: a multicentre randomised controlled trial

Eva Huysmans; Lisa Goudman; Iris Coppieters; Wouter Van Bogaert; Maarten Moens; Ronald Buyl; Jo Nijs; Adriaan Louw; Tine Logghe; Koen Putman; Kelly Ickmans

doi:10.1016/j.bja.2023.05.007

Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy: a multicentre randomised controlled trial

Eva Huysmans, Lisa Goudman, Iris Coppieters, Wouter Van Bogaert, Maarten Moens, Ronald Buyl, Jo Nijs, Adriaan Louw, Tine Logghe, Koen Putman, Kelly Ickmans

Onderzoeksoutput: Article › peer review

13 Citaten (Scopus)

129 Downloads (Pure)

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BACKGROUND: Perioperative education should be improved to decrease unfavourable outcomes after lumbar surgery. This trial aimed to compare effectiveness in terms of pain, quality of life, pain cognition, surgical experience, healthcare use, work resumption, and cost-effectiveness of perioperative pain neuroscience education (PPNE) vs traditional biomedical education (perioperative biomedical education [PBE]) in people undergoing surgery for lumbar radiculopathy.

METHODS: In this multicentre RCT (ClinicalTrials.gov: NCT02630732), patients undergoing surgery for lumbar radiculopathy in three Belgian hospitals were randomised to receive PPNE or PBE. Both groups received one preoperative and one postoperative one-to-one education session and a booklet (balanced interventions), with an essentially different content (PPNE: biopsychosocial; PBE: biomedical). Pain was the primary outcome (Visual Analogue Scales+quantitative sensory testing). Assessments were at 3 days, 6 weeks, and 6 and 12 months after surgery.

RESULTS: Between March 2016 and April 2020, participants were randomly assigned to PPNE (n=58) or PBE (n=62). At 12 months, PPNE did not lead to significantly better pain outcomes, but it did result in more favourable 36-item Short Form Health Survey physical component (additional increase: 46.94; 95% confidence interval [CI]: 14.16-79.73; medium effect), Tampa Scale of Kinesiophobia (additional decrease: 3.15; 95% CI: 0.25-6.04; small effect), and Pain Catastrophising Scale (additional decrease: 6.18; 95% CI: 1.97-10.39; medium effect) scores. Females of the PPNE group showed higher probability for work resumption (95% vs 60% in the PBE group). PPNE was cost-effective compared with PBE (incremental costs: €-2732; incremental quality-adjusted life years: 0.012).

CONCLUSIONS: Perioperative pain neuroscience education showed superior clinical and cost-effectiveness than perioperative biomedical education in people undergoing surgery for lumbar radiculopathy.

CLINICAL TRIAL REGISTRATION: NCT02630732.

Originele taal-2	English
Pagina's (van-tot)	572-585
Aantal pagina's	14
Tijdschrift	British Journal of Anaesthesia
Volume	131
Nummer van het tijdschrift	3
Vroegere onlinedatum	19 jun 2023
DOI's	https://doi.org/10.1016/j.bja.2023.05.007
Status	Published - sep 2023

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10.1016/j.bja.2023.05.007Licentie: CC BY-NC-ND

1-s2.0-S0007091223002428-mainFinal published version, 388 KBLicentie: CC BY-NC-ND

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Back School or Brain School for Patients Undergoing Lumbar Radiculopathy? A Multi-Center Randomized Controlled Trial With Two-Year Follow-Up.
Nijs, J. (Project Leader), Huysmans, E. (Researcher), Moens, M. (Project Leader), Putman, K. (Supervisor), Buyl, R. (Supervisor), Goudman, L. (Researcher), Ickmans, K. (Supervisor), Coppieters, I. (Supervisor), Van Bogaert, W. (Researcher) & Logghe, T. (Related person), VUB, 2021
Dataset
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Nijs, J. (Creator), Huysmans, E. (Creator), Moens, M. (Creator), Putman, K. (Creator), Buyl, R. (Creator), Goudman, L. (Creator), Ickmans, K. (Creator), Coppieters, I. (Creator), Van Bogaert, W. (Creator) & Logghe, T. (Creator), VUB Institutional Data Repository, 13 mrt 2025
Dataset

Citeer dit

Huysmans, E., Goudman, L., Coppieters, I., Van Bogaert, W., Moens, M., Buyl, R., Nijs, J., Louw, A., Logghe, T., Putman, K., & Ickmans, K. (2023). Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy: a multicentre randomised controlled trial. British Journal of Anaesthesia, 131(3), 572-585. https://doi.org/10.1016/j.bja.2023.05.007

Huysmans, Eva ; Goudman, Lisa ; Coppieters, Iris ; Van Bogaert, Wouter ; Moens, Maarten ; Buyl, Ronald ; Nijs, Jo ; Louw, Adriaan ; Logghe, Tine ; Putman, Koen ; Ickmans, Kelly. / Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy : a multicentre randomised controlled trial. In: British Journal of Anaesthesia. 2023 ; Vol. 131, Nr. 3. blz. 572-585.

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title = "Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy: a multicentre randomised controlled trial",

abstract = "BACKGROUND: Perioperative education should be improved to decrease unfavourable outcomes after lumbar surgery. This trial aimed to compare effectiveness in terms of pain, quality of life, pain cognition, surgical experience, healthcare use, work resumption, and cost-effectiveness of perioperative pain neuroscience education (PPNE) vs traditional biomedical education (perioperative biomedical education [PBE]) in people undergoing surgery for lumbar radiculopathy.METHODS: In this multicentre RCT (ClinicalTrials.gov: NCT02630732), patients undergoing surgery for lumbar radiculopathy in three Belgian hospitals were randomised to receive PPNE or PBE. Both groups received one preoperative and one postoperative one-to-one education session and a booklet (balanced interventions), with an essentially different content (PPNE: biopsychosocial; PBE: biomedical). Pain was the primary outcome (Visual Analogue Scales+quantitative sensory testing). Assessments were at 3 days, 6 weeks, and 6 and 12 months after surgery.RESULTS: Between March 2016 and April 2020, participants were randomly assigned to PPNE (n=58) or PBE (n=62). At 12 months, PPNE did not lead to significantly better pain outcomes, but it did result in more favourable 36-item Short Form Health Survey physical component (additional increase: 46.94; 95% confidence interval [CI]: 14.16-79.73; medium effect), Tampa Scale of Kinesiophobia (additional decrease: 3.15; 95% CI: 0.25-6.04; small effect), and Pain Catastrophising Scale (additional decrease: 6.18; 95% CI: 1.97-10.39; medium effect) scores. Females of the PPNE group showed higher probability for work resumption (95% vs 60% in the PBE group). PPNE was cost-effective compared with PBE (incremental costs: €-2732; incremental quality-adjusted life years: 0.012).CONCLUSIONS: Perioperative pain neuroscience education showed superior clinical and cost-effectiveness than perioperative biomedical education in people undergoing surgery for lumbar radiculopathy.CLINICAL TRIAL REGISTRATION: NCT02630732.",

keywords = "lumbar radiculopathy, lumbar surgery, pain education, pain management, pain neuroscience education, prehabilitation",

author = "Eva Huysmans and Lisa Goudman and Iris Coppieters and {Van Bogaert}, Wouter and Maarten Moens and Ronald Buyl and Jo Nijs and Adriaan Louw and Tine Logghe and Koen Putman and Kelly Ickmans",

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doi = "10.1016/j.bja.2023.05.007",

language = "English",

volume = "131",

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Huysmans, E , Goudman, L , Coppieters, I , Van Bogaert, W , Moens, M , Buyl, R , Nijs, J, Louw, A, Logghe, T, Putman, K & Ickmans, K 2023, 'Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy: a multicentre randomised controlled trial', British Journal of Anaesthesia, vol. 131, nr. 3, blz. 572-585. https://doi.org/10.1016/j.bja.2023.05.007

Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy : a multicentre randomised controlled trial. / Huysmans, Eva ; Goudman, Lisa ; Coppieters, Iris ; Van Bogaert, Wouter ; Moens, Maarten ; Buyl, Ronald ; Nijs, Jo; Louw, Adriaan; Logghe, Tine; Putman, Koen ; Ickmans, Kelly.

In: British Journal of Anaesthesia, Vol. 131, Nr. 3, 09.2023, blz. 572-585.

Onderzoeksoutput: Article › peer review

TY - JOUR

T1 - Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy

T2 - a multicentre randomised controlled trial

AU - Huysmans, Eva

AU - Goudman, Lisa

AU - Coppieters, Iris

AU - Van Bogaert, Wouter

AU - Moens, Maarten

AU - Buyl, Ronald

AU - Nijs, Jo

AU - Louw, Adriaan

AU - Logghe, Tine

AU - Putman, Koen

AU - Ickmans, Kelly

PY - 2023/9

Y1 - 2023/9

N2 - BACKGROUND: Perioperative education should be improved to decrease unfavourable outcomes after lumbar surgery. This trial aimed to compare effectiveness in terms of pain, quality of life, pain cognition, surgical experience, healthcare use, work resumption, and cost-effectiveness of perioperative pain neuroscience education (PPNE) vs traditional biomedical education (perioperative biomedical education [PBE]) in people undergoing surgery for lumbar radiculopathy.METHODS: In this multicentre RCT (ClinicalTrials.gov: NCT02630732), patients undergoing surgery for lumbar radiculopathy in three Belgian hospitals were randomised to receive PPNE or PBE. Both groups received one preoperative and one postoperative one-to-one education session and a booklet (balanced interventions), with an essentially different content (PPNE: biopsychosocial; PBE: biomedical). Pain was the primary outcome (Visual Analogue Scales+quantitative sensory testing). Assessments were at 3 days, 6 weeks, and 6 and 12 months after surgery.RESULTS: Between March 2016 and April 2020, participants were randomly assigned to PPNE (n=58) or PBE (n=62). At 12 months, PPNE did not lead to significantly better pain outcomes, but it did result in more favourable 36-item Short Form Health Survey physical component (additional increase: 46.94; 95% confidence interval [CI]: 14.16-79.73; medium effect), Tampa Scale of Kinesiophobia (additional decrease: 3.15; 95% CI: 0.25-6.04; small effect), and Pain Catastrophising Scale (additional decrease: 6.18; 95% CI: 1.97-10.39; medium effect) scores. Females of the PPNE group showed higher probability for work resumption (95% vs 60% in the PBE group). PPNE was cost-effective compared with PBE (incremental costs: €-2732; incremental quality-adjusted life years: 0.012).CONCLUSIONS: Perioperative pain neuroscience education showed superior clinical and cost-effectiveness than perioperative biomedical education in people undergoing surgery for lumbar radiculopathy.CLINICAL TRIAL REGISTRATION: NCT02630732.

AB - BACKGROUND: Perioperative education should be improved to decrease unfavourable outcomes after lumbar surgery. This trial aimed to compare effectiveness in terms of pain, quality of life, pain cognition, surgical experience, healthcare use, work resumption, and cost-effectiveness of perioperative pain neuroscience education (PPNE) vs traditional biomedical education (perioperative biomedical education [PBE]) in people undergoing surgery for lumbar radiculopathy.METHODS: In this multicentre RCT (ClinicalTrials.gov: NCT02630732), patients undergoing surgery for lumbar radiculopathy in three Belgian hospitals were randomised to receive PPNE or PBE. Both groups received one preoperative and one postoperative one-to-one education session and a booklet (balanced interventions), with an essentially different content (PPNE: biopsychosocial; PBE: biomedical). Pain was the primary outcome (Visual Analogue Scales+quantitative sensory testing). Assessments were at 3 days, 6 weeks, and 6 and 12 months after surgery.RESULTS: Between March 2016 and April 2020, participants were randomly assigned to PPNE (n=58) or PBE (n=62). At 12 months, PPNE did not lead to significantly better pain outcomes, but it did result in more favourable 36-item Short Form Health Survey physical component (additional increase: 46.94; 95% confidence interval [CI]: 14.16-79.73; medium effect), Tampa Scale of Kinesiophobia (additional decrease: 3.15; 95% CI: 0.25-6.04; small effect), and Pain Catastrophising Scale (additional decrease: 6.18; 95% CI: 1.97-10.39; medium effect) scores. Females of the PPNE group showed higher probability for work resumption (95% vs 60% in the PBE group). PPNE was cost-effective compared with PBE (incremental costs: €-2732; incremental quality-adjusted life years: 0.012).CONCLUSIONS: Perioperative pain neuroscience education showed superior clinical and cost-effectiveness than perioperative biomedical education in people undergoing surgery for lumbar radiculopathy.CLINICAL TRIAL REGISTRATION: NCT02630732.

KW - lumbar radiculopathy

KW - lumbar surgery

KW - pain education

KW - pain management

KW - pain neuroscience education

KW - prehabilitation

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U2 - 10.1016/j.bja.2023.05.007

DO - 10.1016/j.bja.2023.05.007

M3 - Article

C2 - 37344337

VL - 131

SP - 572

EP - 585

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

IS - 3

ER -

Effect of perioperative pain neuroscience education in people undergoing surgery for lumbar radiculopathy: a multicentre randomised controlled trial

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Back School or Brain School for Patients Undergoing Lumbar Radiculopathy? A Multi-Center Randomized Controlled Trial With Two-Year Follow-Up.

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