Efficacy of additional electrostatic precipitation to intraperitoneal aerosolized chemotherapy in a realistically reconstructed human peritoneal cavity: a computational study

Peritoneal metastasis (PM) is a type of cancer spread in which the peritoneum is affected by numerous tumor nodules. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is an innovative drug delivery method developed to treat PM using laparoscopy. During PIPAC treatment, chemotherapeutics are nebulized as aerosol droplets using a high-pressure injector (Injektron™ 82 M, Medtron, Germany) and an atomizer (Capnopen®, Germany) with the aim to obtain a homogeneous droplet distribution throughout the peritoneal cavity, thereby increasing the effectiveness of intraperitoneal chemotherapy. The goal of the present work was to investigate the effect of additional electrostatic precipitation (ePIPAC) on the aerosol distribution during PIPAC in a realistically reconstructed human peritoneal cavity using computational fluid dynamics (CFD) modeling.