Electrophoresis of serum protein to detect alpha-1-antitrypsin deficiency: 5 illustrative case reports.

Ronald Malfait, Frans Gorus, Claude Sevens

Onderzoeksoutput: Articlepeer review

6 Citaten (Scopus)

Samenvatting

We describe five cases of severe alfa1-antitrypsin (AAT) deficiency to illustrate the importance of visual inspection of electrophoretic patterns of serum proteins. In four patients the diagnosis of AAT deficiency was clinically unsuspected; in the other patient, the electrophoretic pattern was the first clue to confirm the diagnosis. Densitometric scanning of these patterns invariably overestimated the concentration of alfa1-globulin. By visually inspecting electrophoretic strips instead of relying on densitometry, clinical chemists can help detect AAT deficiency earlier.
Originele taal-2English
Pagina's (van-tot)1397-1399
Aantal pagina's3
TijdschriftClinical Chemistry
Volume31
StatusPublished - 1985

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