Evaluation of Micro-Pillar Array Columns (µPAC) Combined with High Resolution Mass Spectrometry for Lipidomics

Koen Sandra, Jonathan Vandenbussche, Ruben 't Kindt, Bo Claerebout, Jeff Op De Beeck, Wim De Malsche, Gert Desmet, Pat Sandra

Onderzoeksoutput: Articlepeer review

Samenvatting

In the 21st century, numerous advances have been made in liquid chromatography (LC) column technology. The best known are columns packed with sub-2-µm porous particles or sub-3-µm superficially particles, and monolithic columns. Another very novel and original development is micro-pillar array columns (µPAC). µPACs are produced by a lithographic etching process to create a perfectly ordered separation bed on a silicon chip. Although the performance in terms of efficiency has been illustrated, the applicability for analysis of real complex samples has yet to be fully demonstrated. This article illustrates that state‑of‑the‑art µPAC columns coated with octadecyl are applicable for a challenging application such as lipidomics. The performance is illustrated with the analysis of human blood plasma lipids.
Originele taal-2English
Pagina's (van-tot)6-13
Aantal pagina's7
TijdschriftLC-GC Europe
Volume30
Nummer van het tijdschrift6
StatusPublished - 2017

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