Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls

Amber H Nuyts; Peter Ponsaerts; Viggo F I Van Tendeloo; Wai-Ping Lee; Barbara Stein; Guy Nagels; Marie B D'hooghe; Barbara Willekens; Patrick Cras; Kristien Wouters; Herman Goossens; Zwi N Berneman; Nathalie Cools

doi:10.1016/j.jcyt.2014.02.016

Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls

Amber H Nuyts, Peter Ponsaerts, Viggo F I Van Tendeloo, Wai-Ping Lee, Barbara Stein, Guy Nagels, Marie B D'hooghe, Barbara Willekens, Patrick Cras, Kristien Wouters, Herman Goossens, Zwi N Berneman, Nathalie Cools

Onderzoeksoutput: Article › peer review

10 Citaten (Scopus)

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BACKGROUND AIMS: Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS).

METHODS: We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls.

RESULTS: Except for an increase in the number of C-C chemokine receptor 7-expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells.

CONCLUSIONS: Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.

Originele taal-2	English
Pagina's (van-tot)	1024-1030
Aantal pagina's	7
Tijdschrift	Cytotherapy
Volume	16
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1016/j.jcyt.2014.02.016
Status	Published - jul. 2014

Keywords

Adult
Aged
Cell Differentiation
Dendritic Cells
Female
Humans
Immunotherapy
Lymphocyte Activation
Male
Middle Aged
Monocytes
Multiple Sclerosis
Receptors, CCR7
T-Lymphocytes
Vaccination

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10.1016/j.jcyt.2014.02.016

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Nuyts, A. H., Ponsaerts, P., Van Tendeloo, V. F. I., Lee, W.-P., Stein, B., Nagels, G., D'hooghe, M. B., Willekens, B., Cras, P., Wouters, K., Goossens, H., Berneman, Z. N., & Cools, N. (2014). Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls. Cytotherapy, 16(7), 1024-1030. https://doi.org/10.1016/j.jcyt.2014.02.016

@article{e25d741e9b534b8598e4213bc5275fe9,

title = "Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls",

abstract = "BACKGROUND AIMS: Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS).METHODS: We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls.RESULTS: Except for an increase in the number of C-C chemokine receptor 7-expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells.CONCLUSIONS: Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.",

keywords = "Adult, Aged, Cell Differentiation, Dendritic Cells, Female, Humans, Immunotherapy, Lymphocyte Activation, Male, Middle Aged, Monocytes, Multiple Sclerosis, Receptors, CCR7, T-Lymphocytes, Vaccination",

author = "Nuyts, {Amber H} and Peter Ponsaerts and {Van Tendeloo}, {Viggo F I} and Wai-Ping Lee and Barbara Stein and Guy Nagels and D'hooghe, {Marie B} and Barbara Willekens and Patrick Cras and Kristien Wouters and Herman Goossens and Berneman, {Zwi N} and Nathalie Cools",

year = "2014",

month = jul,

doi = "10.1016/j.jcyt.2014.02.016",

language = "English",

volume = "16",

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journal = "Cytotherapy",

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Nuyts, AH, Ponsaerts, P, Van Tendeloo, VFI, Lee, W-P, Stein, B, Nagels, G , D'hooghe, MB, Willekens, B, Cras, P, Wouters, K, Goossens, H, Berneman, ZN & Cools, N 2014, 'Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls', Cytotherapy, vol. 16, nr. 7, blz. 1024-1030. https://doi.org/10.1016/j.jcyt.2014.02.016

TY - JOUR

T1 - Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls

AU - Nuyts, Amber H

AU - Ponsaerts, Peter

AU - Van Tendeloo, Viggo F I

AU - Lee, Wai-Ping

AU - Stein, Barbara

AU - Nagels, Guy

AU - D'hooghe, Marie B

AU - Willekens, Barbara

AU - Cras, Patrick

AU - Wouters, Kristien

AU - Goossens, Herman

AU - Berneman, Zwi N

AU - Cools, Nathalie

PY - 2014/7

Y1 - 2014/7

N2 - BACKGROUND AIMS: Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS).METHODS: We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls.RESULTS: Except for an increase in the number of C-C chemokine receptor 7-expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells.CONCLUSIONS: Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.

AB - BACKGROUND AIMS: Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS).METHODS: We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls.RESULTS: Except for an increase in the number of C-C chemokine receptor 7-expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells.CONCLUSIONS: Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.

KW - Adult

KW - Aged

KW - Cell Differentiation

KW - Dendritic Cells

KW - Female

KW - Humans

KW - Immunotherapy

KW - Lymphocyte Activation

KW - Male

KW - Middle Aged

KW - Monocytes

KW - Multiple Sclerosis

KW - Receptors, CCR7

KW - T-Lymphocytes

KW - Vaccination

U2 - 10.1016/j.jcyt.2014.02.016

DO - 10.1016/j.jcyt.2014.02.016

M3 - Article

C2 - 24856897

SN - 1465-3249

VL - 16

SP - 1024

EP - 1030

JO - Cytotherapy

JF - Cytotherapy

IS - 7

ER -

Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls

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Keywords

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