Experimental models of hepatotoxicity related to acute liver failure

Michaël Maes; Mathieu Vinken; Hartmut Jaeschke

doi:10.1016/j.taap.2015.11.016

Experimental models of hepatotoxicity related to acute liver failure

Michaël Maes, Mathieu Vinken, Hartmut Jaeschke

Onderzoeksoutput: Article › peer review

180 Citaten (Scopus)

358 Downloads (Pure)

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Acute liver failure can be the consequence of various etiologies, with most cases arising from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the management of acute liver failure continues to be one of the most challenging problems in clinical medicine. The availability of adequate experimental models is of crucial importance to provide a better understanding of this condition and to allow identification of novel drug targets, testing the efficacy of new therapeutic interventions and acting as models for assessing mechanisms of toxicity. Experimental models of hepatotoxicity related to acute liver failure rely on surgical procedures, chemical exposure or viral infection. Each of these models has a number of strengths and weaknesses. This paper specifically reviews commonly used chemical in vivo and in vitro models of hepatotoxicity associated with acute liver failure.

Originele taal-2	English
Pagina's (van-tot)	86-97
Aantal pagina's	12
Tijdschrift	Toxicology and Applied Pharmacology
Volume	290
DOI's	https://doi.org/10.1016/j.taap.2015.11.016
Status	Published - 1 jan. 2016

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10.1016/j.taap.2015.11.016

Maes et al TAAP Experimental models of hepatotoxicity related to acute liver failure PMCOther version, 1,81 MB

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1 Actief
3 Afgelopen

OZR2651: Internationale alliantie-onderzoeksgroep: hepatische connexines en pannexines
Vinken, M. (Administrative Promotor), Rogiers, V. (Co-Promoter), Cogliati, B. (Co-Promoter) & Dagli, M. L. (Co-Promoter)
1/08/14 → 1/07/26
Project: Fundamenteel
EU457: CONNECT
Vinken, M. (Administrative Promotor)
1/03/14 → 28/02/19
Project: Fundamenteel
FWOAL723: Karakterisatie van op connexine43- en pannexinel-gebaseerde hemikanalen als weefselbiomerkers en farmacologische doelwitten in acuut leverfalen: een gecombineerde in vitro-in vivo studie
Vinken, M. (Administrative Promotor), Rogiers, V. (Co-Promoter) & Vanhaecke, T. (Co-Promoter)
1/01/14 → 31/12/17
Project: Fundamenteel

Connexin32: a mediator of acetaminophen-induced liver injury?
Maes, M., Mcgill, M. R., da Silva, T. C., Lebofsky, M., Monteiro de Araújo, C. M., Tiburcio, T., Alves Pereira, I. V., Willebrords, J., Crespo Yanguas, S., Farhood, A., Zaidan Dagli, M. L., Jaeschke, H., Cogliati, B. & Vinken, M., 1 mei 2016, In: Toxicology Mechanism and Methods. 26, 2, blz. 88-96 9 blz.
Onderzoeksoutput: Article › peer review
14 Citaten (Scopus)
Involvement of connexin43 in acetaminophen-induced liver injury
Maes, M., Mcgill, M. R., da Silva, T. C., Abels, C., Lebofsky, M., Monteiro de Araújo, C. M., Tiburcio, T., Alves Pereira, I. V., Willebrords, J., Crespo Yanguas, S., Farhood, A., Beschin, A., Van Ginderachter, J., Zaidan Dagli, M. L., Jaeschke, H., Cogliati, B. & Vinken, M., 1 jun. 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 6, blz. 1111-1121 11 blz.
Onderzoeksoutput: Article › peer review
33 Citaten (Scopus)

Citeer dit

@article{b13430052b464d5bbab03000e955494d,

title = "Experimental models of hepatotoxicity related to acute liver failure",

abstract = "Acute liver failure can be the consequence of various etiologies, with most cases arising from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the management of acute liver failure continues to be one of the most challenging problems in clinical medicine. The availability of adequate experimental models is of crucial importance to provide a better understanding of this condition and to allow identification of novel drug targets, testing the efficacy of new therapeutic interventions and acting as models for assessing mechanisms of toxicity. Experimental models of hepatotoxicity related to acute liver failure rely on surgical procedures, chemical exposure or viral infection. Each of these models has a number of strengths and weaknesses. This paper specifically reviews commonly used chemical in vivo and in vitro models of hepatotoxicity associated with acute liver failure.",

keywords = "hepatotoxicity, acute liver failure, acetaminophen, D-galactosamine, Fas ligand, concanavalin A",

author = "Micha{\"e}l Maes and Mathieu Vinken and Hartmut Jaeschke",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.taap.2015.11.016",

language = "English",

volume = "290",

pages = "86--97",

journal = "Toxicology and Applied Pharmacology",

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publisher = "Academic Press Inc.",

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T1 - Experimental models of hepatotoxicity related to acute liver failure

AU - Maes, Michaël

AU - Vinken, Mathieu

AU - Jaeschke, Hartmut

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Acute liver failure can be the consequence of various etiologies, with most cases arising from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the management of acute liver failure continues to be one of the most challenging problems in clinical medicine. The availability of adequate experimental models is of crucial importance to provide a better understanding of this condition and to allow identification of novel drug targets, testing the efficacy of new therapeutic interventions and acting as models for assessing mechanisms of toxicity. Experimental models of hepatotoxicity related to acute liver failure rely on surgical procedures, chemical exposure or viral infection. Each of these models has a number of strengths and weaknesses. This paper specifically reviews commonly used chemical in vivo and in vitro models of hepatotoxicity associated with acute liver failure.

AB - Acute liver failure can be the consequence of various etiologies, with most cases arising from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the management of acute liver failure continues to be one of the most challenging problems in clinical medicine. The availability of adequate experimental models is of crucial importance to provide a better understanding of this condition and to allow identification of novel drug targets, testing the efficacy of new therapeutic interventions and acting as models for assessing mechanisms of toxicity. Experimental models of hepatotoxicity related to acute liver failure rely on surgical procedures, chemical exposure or viral infection. Each of these models has a number of strengths and weaknesses. This paper specifically reviews commonly used chemical in vivo and in vitro models of hepatotoxicity associated with acute liver failure.

KW - hepatotoxicity

KW - acute liver failure

KW - acetaminophen

KW - D-galactosamine

KW - Fas ligand

KW - concanavalin A

U2 - 10.1016/j.taap.2015.11.016

DO - 10.1016/j.taap.2015.11.016

M3 - Article

SN - 0041-008X

VL - 290

SP - 86

EP - 97

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

ER -

Experimental models of hepatotoxicity related to acute liver failure

Samenvatting

Toegang tot document

Handle.net

Vingerafdruk

Projecten

OZR2651: Internationale alliantie-onderzoeksgroep: hepatische connexines en pannexines

EU457: CONNECT

FWOAL723: Karakterisatie van op connexine43- en pannexinel-gebaseerde hemikanalen als weefselbiomerkers en farmacologische doelwitten in acuut leverfalen: een gecombineerde in vitro-in vivo studie

Onderzoekersoutput

Connexin32: a mediator of acetaminophen-induced liver injury?

Involvement of connexin43 in acetaminophen-induced liver injury

Citeer dit