TY - JOUR
T1 - Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies
AU - d’Otreppe, Juliette
AU - Patino-García, Daniel
AU - Piekos, Patryk
AU - Codt, Matthieu de
AU - Manavella, Diego D.
AU - Courtoy, Guillaume E.
AU - Orellana, Renan
N1 - Funding Information:
The authors wish to thank Victoria Torok (B.Sc.) for revising the English language of the manuscript.
Publisher Copyright:
© 2024 by the authors.
PY - 2024/2/1
Y1 - 2024/2/1
N2 - Adenomyosis (ADM) is a multifaceted uterine pathology characterized by the ectopic infiltration of endometrial tissue into the myometrium, affecting approximately 20% of women in the reproductive age group seeking gynecological care. This condition manifests as a range of debilitating symptoms, including dysmenorrhea, menorrhagia, impaired fertility, and heightened susceptibility to miscarriage and obstetric complications. Substantial research has been dedicated to exploring its underlying molecular mechanisms and developing non-invasive precision medical therapies. ADM is primarily characterized by a dysregulation in sex steroid hormone homeostasis, particularly estrogen and progesterone. However, emerging evidence suggests that additional endocrine mediators and disruptors may play contributory roles in the etiology of ADM. Genetic and epigenetic alterations of endocrine signaling pathways have been implicated as prevailing mechanisms underlying the development and progression of the disease. The present review aims to provide an updated and comprehensive overview of the current understanding of the pathophysiology of ADM, with a particular emphasis on the dysregulated hormonal milieu and the potential involvement of endocrine disruptors. By elucidating these intricate molecular mechanisms, this review seeks to pave the way for novel research directions in the development of targeted therapeutic strategies for ADM management.
AB - Adenomyosis (ADM) is a multifaceted uterine pathology characterized by the ectopic infiltration of endometrial tissue into the myometrium, affecting approximately 20% of women in the reproductive age group seeking gynecological care. This condition manifests as a range of debilitating symptoms, including dysmenorrhea, menorrhagia, impaired fertility, and heightened susceptibility to miscarriage and obstetric complications. Substantial research has been dedicated to exploring its underlying molecular mechanisms and developing non-invasive precision medical therapies. ADM is primarily characterized by a dysregulation in sex steroid hormone homeostasis, particularly estrogen and progesterone. However, emerging evidence suggests that additional endocrine mediators and disruptors may play contributory roles in the etiology of ADM. Genetic and epigenetic alterations of endocrine signaling pathways have been implicated as prevailing mechanisms underlying the development and progression of the disease. The present review aims to provide an updated and comprehensive overview of the current understanding of the pathophysiology of ADM, with a particular emphasis on the dysregulated hormonal milieu and the potential involvement of endocrine disruptors. By elucidating these intricate molecular mechanisms, this review seeks to pave the way for novel research directions in the development of targeted therapeutic strategies for ADM management.
UR - https://doi.org/10.3390/endocrines5010004
UR - http://www.scopus.com/inward/record.url?scp=85202636550&partnerID=8YFLogxK
U2 - 10.3390/endocrines5010004
DO - 10.3390/endocrines5010004
M3 - Article
VL - 5
SP - 46
EP - 71
JO - Endocrines
JF - Endocrines
SN - 2673-396X
IS - 1
ER -