TY - JOUR
T1 - Freezing of gait in Parkinson's disease is associated with impaired conflict resolution
AU - Vandenbossche, Jochen
AU - Deroost, Natacha
AU - Soetens, Eric
AU - Spildooren, Joke
AU - Vercruysse, Sarah
AU - Nieuwboer, Alice
AU - Kerckhofs, Eric
PY - 2011/10/25
Y1 - 2011/10/25
N2 - Background: Freezing of gait (FOG) in Parkinson's disease (PD) may involve executive dysfunction. We examined whether executive functioning and attention are more affected in patients with FOG compared to those without and to determine whether these processes are influenced by antiparkinson medication. Methods: Eleven PD patients with FOG, 11 without FOG and 10 healthy control subjects, matched for age, gender and education, participated. General motor, mental and cognitive screening tests, as well as specific neuropsychological assessment of executive functions and the Attention Network Test (ANT) were administered. The ANT was conducted in both ON and OFF phases in a counterbalanced design to determine medication-specific effects. Results: FOG showed a clear association with impairment in the executive control network for conflict resolution (inhibition of unwanted responses and impaired response selection), compared to non-freezers and healthy controls, F(2,28) = 5.41, p=.01. Orienting and alerting function did not differ between groups, F <1. Other executive functions, such as abstract problem solving and mental flexibility were not associated with FOG (p>.10). Antiparkinson medication did not ameliorate conflict resolution (p>.10), although orienting attention improved with medication, F(1,17) = 9.81, p
AB - Background: Freezing of gait (FOG) in Parkinson's disease (PD) may involve executive dysfunction. We examined whether executive functioning and attention are more affected in patients with FOG compared to those without and to determine whether these processes are influenced by antiparkinson medication. Methods: Eleven PD patients with FOG, 11 without FOG and 10 healthy control subjects, matched for age, gender and education, participated. General motor, mental and cognitive screening tests, as well as specific neuropsychological assessment of executive functions and the Attention Network Test (ANT) were administered. The ANT was conducted in both ON and OFF phases in a counterbalanced design to determine medication-specific effects. Results: FOG showed a clear association with impairment in the executive control network for conflict resolution (inhibition of unwanted responses and impaired response selection), compared to non-freezers and healthy controls, F(2,28) = 5.41, p=.01. Orienting and alerting function did not differ between groups, F <1. Other executive functions, such as abstract problem solving and mental flexibility were not associated with FOG (p>.10). Antiparkinson medication did not ameliorate conflict resolution (p>.10), although orienting attention improved with medication, F(1,17) = 9.81, p
KW - parkinson's disease
KW - freezing of gait
KW - conflict resolution
U2 - https://doi.org/10.1177/1545968311403493
DO - https://doi.org/10.1177/1545968311403493
M3 - Article
VL - 8
SP - 765
EP - 773
JO - Neurorehabilitation and Neural Repair
JF - Neurorehabilitation and Neural Repair
SN - 1545-9683
IS - 8
ER -