4 Citaten (Scopus)
23 Downloads (Pure)

Samenvatting

Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the identified genes code for proteins expressed in neurons, glial cells, or vessels, all of which increase susceptibility to cortical spreading depression. The study of monogenic migraines has shown that the neurovascular unit plays a prominent role in migraine. Genome-wide association studies have identified numerous susceptibility variants that each result in only a small increase in overall migraine risk. The more than 180 known variants belong to several complex networks of “pro-migraine” molecular abnormalities, which are mainly neuronal or vascular. Genetics has also highlighted the importance of shared genetic factors between migraine and its major co-morbidities, including depression and high blood pressure. Further studies are still needed to map all of the susceptibility loci for migraine and then to understand how these genomic variants lead to migraine cell phenotypes.

Originele taal-2English
Artikelnummer12
Aantal pagina's23
TijdschriftJournal of Headache and Pain
Volume24
Nummer van het tijdschrift1
Vroegere onlinedatumdec 2022
DOI's
StatusPublished - 20 feb 2023

Bibliografische nota

Funding Information:
Anne Ducros had received personal fees for board membership and/or speaking from Allergan/Abbvie, Lilly, Lundbeck, Novartis, Pfizer, Teva, is associate editor of Cephalalgia and past-president of the French Headache Society, and has received research grants for her institution (CHU de Montpellier) from the Programme Hospitalier de Recherche Clinique (PHRC) and from Pfizer.

Funding Information:
Lou Grangeon has received travel and accommodation expenses from Lundbeck, not related to the submitted work. Kristin Sophie Lange has received travel and accommodation expenses from Acticor Biotech and TEVA GmbH, not related to the submitted work. Wietse Wiels is a fundamental research scholar of the Flanders Scientific Research Fund (FWO). Anne Ducros had received personal fees for board membership and/or speaking from Allergan/Abbvie, Lilly, Lundbeck, Novartis, Pfizer, Teva, is associate editor of Cephalalgia and past-president of the French Headache Society, and has received research grants for her institution (CHU de Montpellier) from the Programme Hospitalier de Recherche Clinique (PHRC) and from Pfizer.

Publisher Copyright:
© 2023, The Author(s).

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

Vingerafdruk

Duik in de onderzoeksthema's van 'Genetics of migraine: where are we now?'. Samen vormen ze een unieke vingerafdruk.

Citeer dit