@article{ca4a9add60d64600a09a25dfc915512a,
title = "Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes",
abstract = "Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.",
keywords = "Algorithms, Antigens, CD/genetics, CTLA-4 Antigen, Chromosome Mapping/methods, Chromosomes, Human, Pair 1/genetics, Chromosomes, Human, Pair 17/genetics, Chromosomes, Human, Pair 2/genetics, DEAD-box RNA Helicases/genetics, DNA/genetics, Diabetes Mellitus, Type 1/epidemiology, Family, Female, Genome-Wide Association Study, Genotype, HLA Antigens/genetics, Humans, Interferon-Induced Helicase, IFIH1, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide/genetics, Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics, Risk Assessment, Siblings",
author = "{Type 1 Diabetes Genetics Consortium} and Barrett, {Jeffrey C} and Clayton, {David G} and Patrick Concannon and Beena Akolkar and Cooper, {Jason D} and Erlich, {Henry A} and C{\'e}cile Julier and Grant Morahan and J{\o}rn Nerup and Concepcion Nierras and Vincent Plagnol and Flemming Pociot and Helen Schuilenburg and Smyth, {Deborah J} and Helen Stevens and Todd, {John A} and Walker, {Neil M} and Rich, {Stephen S} and {Van Der Auwera}, Bart",
year = "2009",
month = jun,
doi = "10.1038/ng.381",
language = "English",
volume = "41",
pages = "703--707",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "6",
}