@article{49d60cf54c404fe6ade7a4e3bf4a44fa,
title = "GSDME: A Potential Ally in Cancer Detection and Treatment",
abstract = "Gasdermin E (GSDME) is an executioner of caspase-3 mediated regulated pyroptosis, and as such plays an important role in several cancers. Recent findings highlighted the potential of GSDME as a biomarker that can be implemented in cancer diagnosis, monitoring, and therapy.",
keywords = "Antineoplastic Agents/pharmacology, Biomarkers, Tumor/agonists, Cell Line, Tumor, DNA Methylation, Early Detection of Cancer/methods, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Humans, Loss of Function Mutation, Molecular Targeted Therapy/methods, Neoplasms/diagnosis, Prognosis, Promoter Regions, Genetic/genetics, Pyroptosis/drug effects, Receptors, Estrogen/genetics, Risk Assessment/methods",
author = "J Ibrahim and {De Schutter}, E and {Op de Beeck}, K",
note = "Funding Information: Research by JI and KODB in the lab of Professor Guy Van Camp is supported by research grants awarded by the University of Antwerp ( BOF/Methusalem grant 40790 , IOF/SBO 43782 , BOF/TOP 39705 ). JI is supported by a PhD fellowship of the Research Foundation – Flanders (FWO; 11B5220N ). Research by ED in the unit of Professor Peter Vandenabeele was supported by EOS MODEL-IDI , FWO research grants ( G.0E04.16N , G.0C76.18N , G.0B71.18N , G.0B96.20N ), Methusalem ( BOF16/MET_V/007 ), Foundation against Cancer ( F/2016/865 , F/2020/1505 ), CRIG and GIGG consortia, and VIB. The authors acknowledge Professor Guy Van Camp for critically reading the manuscript and contributing to its final form. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
doi = "10.1016/j.trecan.2020.12.002",
language = "English",
volume = "7",
pages = "392--394",
journal = "Trends in cancer",
issn = "2405-8033",
publisher = "Elsevier",
number = "5",
}