Healthcare resource use and cost implications of low dose methoxyflurane for severe trauma-related pain: a qualitative study

Pieter Dylst, Angela Solaman, Marc Gillis, Sara Dickerson, James Kenworthy, Said Hachimi-Idrissi

Onderzoeksoutput: Articlepeer review

Samenvatting

Aims: Management of moderate-to-severe trauma-associated pain is often reported as suboptimal, due in part to limitations associated with frequently used analgesics. Low-dose methoxyflurane (LDM) is an inhaled, non-opioid analgesic, recently approved for emergency relief of moderate-to-severe trauma-associated pain in conscious adults. This study assessed the perspective of healthcare professionals (HCPs) with regard to the time to analgesia and healthcare cost of LDM versus morphine IV, for patients with severe trauma-related pain receiving emergency care in Belgium. Materials and methods: Interviews and questionnaires were completed by four healthcare HCPs providing emergency care at different hospitals in Belgium. Processes describing analgesic provision in pre-hospital and hospital emergency department (ED) settings were qualitatively mapped and a cost model applied which included reimbursed analgesic costs, time spent by HCPs making analgesic treatment decisions, preparing and administering the analgesic, and post-dose monitoring and management of analgesic-related adverse events (AEs). Results: LDM was associated with substantial time and costs savings per patient, largely due to no requirement for AE monitoring. Compared with morphine IV, LDM in the hospital ED was associated with a time saving of 4 minutes to analgesic provision (35 vs 39 min) and ≥224 min in total (35 vs ≥259 min; including monitoring and managing AEs). In the pre-hospital setting, LDM was also associated with a time saving of 4 minutes to analgesic provision (21 vs 25 min) and 198 minutes in total. The corresponded total cost savings with LDM vs morphine IV were ≥€27.32 and ≥€17.95 in the ED or prehospital setting, respectively. Conclusions: The cost model showed that LDM was associated with substantial time and costs savings versus morphine IV for severe trauma-related emergency pain in pre-hospital and hospital ED settings in Belgium.

Originele taal-2English
Pagina's (van-tot)248-256
Aantal pagina's9
TijdschriftTrauma
Volume24
Nummer van het tijdschrift3
DOI's
StatusPublished - jul 2022

Bibliografische nota

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was conducted by Suazio Consulting, funded by Mundipharma Comm VA Belgium. Authors from Mundibiopharma Ltd. and Mundipharma Comm VA Belgium participated in the data analysis and interpretation, and critically reviewed the manuscript for intellectual content. Mundibiopharma Ltd also funded professional medical writing support.

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was conducted by Suazio Consulting, funded by Mundipharma Comm VA Belgium. Authors from Mundibiopharma Ltd. and Mundipharma Comm VA Belgium participated in the data analysis and interpretation, and critically reviewed the manuscript for intellectual content. Mundibiopharma Ltd also funded professional medical writing support.

Funding Information:
Medical writing support was provided by Siân Marshall PhD of SIANTIFIX Ltd, Cambridgeshire, UK, and was funded by Mundibiopharma Ltd.

Publisher Copyright:
© The Author(s) 2021.

Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.

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