Hemorrhagic regression of melanoma metastases during therapeutic vaccination: a report of three cases

L. Pierret, N. Van Baren, Aude Bonehill, Jurgen Corthals, An Van Nuffel, Carlo Heirman, Truus Roelandt, Arlette De Coninck, Ivan Van Riet, Ellen Degreef, Annieta Goossens, Guy Verfaillie, Diane Roseeuw, Kris Thielemans, Bart Neyns

Onderzoeksoutput: Article

3 Citaten (Scopus)

Samenvatting

Melanoma metastases are characterized by pronounced neo-angiogenesis and spontaneous bleeding frequently occurring within central nervous system metastases. Clinically apparent spontaneous hemorrhage within subcutaneous melanoma metastases, however, is a rare event that coincides with progression of such metastases. We report, to our knowledge the first observation, on regression of subcutaneous metastases with hemorrhage of the overlying skin in three patients with stage IV melanoma who participated in clinical trials on therapeutic vaccination. In two patients, loss of arterial flow on Doppler ultrasound imaging was documented in the metastasis at the time of hematoma formation. One patient suffered from an intracranial hemorrhage in a subcentimetric brain metastasis coincident with the hemorrhagic regression of some of his skin metastases.
Originele taal-2English
Pagina's (van-tot)385-390
Aantal pagina's5
TijdschriftMelanoma Res.
Volume19
Nummer van het tijdschriftDecember
StatusPublished - 2009

Vingerafdruk

Duik in de onderzoeksthema's van 'Hemorrhagic regression of melanoma metastases during therapeutic vaccination: a report of three cases'. Samen vormen ze een unieke vingerafdruk.

Citeer dit