Hepatic cell junctions: pulling a double-duty

Raf Van Campenhout; Mathieu Vinken

doi:10.1111/liv.16045

Hepatic cell junctions: pulling a double-duty

Raf Van Campenhout, Mathieu Vinken

Onderzoeksoutput: Article › peer review

2 Citaten (Scopus)

48 Downloads (Pure)

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Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.

Originele taal-2	English
Pagina's (van-tot)	2873-2889
Aantal pagina's	17
Tijdschrift	Liver International
Volume	44
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.1111/liv.16045
Status	Published - nov. 2024

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Publisher Copyright:
© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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10.1111/liv.16045Licentie: Unspecified

112968104Accepted author manuscript, 790 KBLicentie: Unspecified

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1 Afgelopen
2 Actief

FWOAL1070: De rol van pannexine1 kanalen in niet-alcoholische steatohepatitis: therapeutische en diagnostische relevantie.
Vinken, M. (Administrative Promotor)
1/01/23 → 31/12/26
Project: Fundamenteel
OZRMETH6: Cellulaire communicatie als doelwit en biomerker in leverziekte en levertoxiciteit: van fundamenteel onderzoek naar klinische toepassing
Vinken, M. (Administrative Promotor)
1/01/21 → 31/12/27
Project: Fundamenteel
EU624: Productie van modulatoren van de volgende generatie van pannexinen en connexines als nieuwe therapeutica bij de behandeling van inflammatoire cardiovasculaire, lever- en gewrichtsziekten.
Vinken, M. (Administrative Promotor) & Ballet, S. (Co-Promoter)
European Commission
1/03/20 → 28/02/25
Project: Fundamenteel

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title = "Hepatic cell junctions: pulling a double-duty",

abstract = "Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.",

author = "{Van Campenhout}, Raf and Mathieu Vinken",

note = "Funding Information: This work was financially supported by the European Horizon 2020 Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders-Belgium (grants G012318N, G020018N and G0F7219N), the Methusalem program of the Flemish Government and the University Hospital of the Vrije Universiteit Brussel-Belgium (Scientific Fund Willy Gepts). Funding Information: This work was financially supported by the European Horizon 2020 Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders\u2010Belgium (grants G012318N, G020018N and G0F7219N), the Methusalem program of the Flemish Government and the University Hospital of the Vrije Universiteit Brussel\u2010Belgium (Scientific Fund Willy Gepts). Publisher Copyright: {\textcopyright} 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2024",

month = nov,

doi = "10.1111/liv.16045",

language = "English",

volume = "44",

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journal = "Liver International",

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AU - Vinken, Mathieu

N1 - Funding Information: This work was financially supported by the European Horizon 2020 Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders-Belgium (grants G012318N, G020018N and G0F7219N), the Methusalem program of the Flemish Government and the University Hospital of the Vrije Universiteit Brussel-Belgium (Scientific Fund Willy Gepts). Funding Information: This work was financially supported by the European Horizon 2020 Future and Emerging Technologies program (grant 858014), the Research Foundation Flanders\u2010Belgium (grants G012318N, G020018N and G0F7219N), the Methusalem program of the Flemish Government and the University Hospital of the Vrije Universiteit Brussel\u2010Belgium (Scientific Fund Willy Gepts). Publisher Copyright: © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2024/11

Y1 - 2024/11

N2 - Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.

AB - Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.

UR - http://www.scopus.com/inward/record.url?scp=85200677268&partnerID=8YFLogxK

U2 - 10.1111/liv.16045

DO - 10.1111/liv.16045

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SN - 1478-3223

VL - 44

SP - 2873

EP - 2889

JO - Liver International

JF - Liver International

IS - 11

ER -

Hepatic cell junctions: pulling a double-duty

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Andere bestanden en links

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Projecten

FWOAL1070: De rol van pannexine1 kanalen in niet-alcoholische steatohepatitis: therapeutische en diagnostische relevantie.

OZRMETH6: Cellulaire communicatie als doelwit en biomerker in leverziekte en levertoxiciteit: van fundamenteel onderzoek naar klinische toepassing

EU624: Productie van modulatoren van de volgende generatie van pannexinen en connexines als nieuwe therapeutica bij de behandeling van inflammatoire cardiovasculaire, lever- en gewrichtsziekten.

Citeer dit