Hormonal changes during a spontaneous attack of hypokalemic periodic paralysis

Jacques De Keyser, Ronald Malfait, A. Van Steirteghem, Guy Ebinger, J. Smitz

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Samenvatting

We studied the hormonal changes during a spontaneous attack of hypokalemic periodic paralysis in a 20-year-old man, before and after treatment with potassium chloride. During paralysis, we observed high circulating levels of insulin, epinephrine, norepinephrine, growth hormone, ACTH and cortisol, most likely reflecting a condition of stress. Normalization of all these hormones occurred with recovery. Plasma aldosterone concentrations were normal. The increased plasma levels of insulin, but also of catecholamines and growth hormone, created a condition promoting potassium uptake in muscle cells. We suggest that stress may play a role in the pathophysiology of the paralytic attacks in this disorder.
Originele taal-2English
Pagina's (van-tot)60-64
Aantal pagina's5
TijdschriftEur Neurol
Volume26
StatusPublished - 1987

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