Immunomodulatory drugs restore effector cell immune functions in myeloma patients with low disease burden after autologous stem cell transplantation

Karel Fostier, Jurgen Corthals, Carlo Heirman, Joeri Aerts, Kristiaan Thielemans, Henri Schots, Brenda De Keersmaecker

Onderzoeksoutput: Meeting abstract (Journal)

Samenvatting

The micro-environment in multiple myeloma (MM) is highly immunosuppressive with increased numbers of regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) favoring tumorcell survival and hampering immunotherapeutic strategies such as dendritic cell vaccination. Immunomodulatory drugs (IMiDs) are known to enhance T- and NK-cell function. In this study we evaluated the effects of low dose (0.5 microM) lenalidomide (Len) and pomalidomide (Pom) on the functionality of CD8+ and CD4+ T cells, MDSCs, Tregs and ex-vivo generated mononuclear derived dendritic cells (moDCs) obtained from MM patients after first autologous stem cell transplantation (ASCT). Peripheral blood mononuclear cell fractions were obtained by leukapheresis from 9 MM patients (age 29-62 years), in very good partial response (4/9) or complete response (5/9) after ASCT.
Originele taal-2English
Pagina's (van-tot)3214-3214
TijdschriftBlood
Volume122
Nummer van het tijdschrift21
StatusPublished - dec 2013

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