Samenvatting
The anti-depressive working mechanisms of accelerated intermittent theta-burst stimulation (aiTBS) are still poorly understood. It has been suggested that an important effect of iTBS may work through modulating the endocrinological responses of the hypothalamic-pituitary-adrenal (HPA) axis, such as cortisol secretion. The present study aimed to investigate the influence of individual differences in state anxiety on the effects of two consecutive iTBS sessions on cortisol secretion after confrontation with a social evaluative stressor. Using a sham-controlled crossover design, two sessions of iTBS over the left Dorsolateral Prefrontal Cortex (DLPFC) were administered to 38 healthy females after they were confronted with the Trier Social Stress Test (TSST). Our results indicate that two iTBS sessions over the left DLPFC significantly increases HPA-axis sensitivity, resulting in higher cortisol secretion, specifically in women scoring high on state anxiety. Our findings suggest that individual characteristics such as state anxiety and stress related physiological reaction like cortisol secretion might be of interest to explain neurobiological responses to non-invasive brain stimulation. Keywords: iTBS, cortisol, state anxiety, TSST
Originele taal-2 | English |
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Pagina's (van-tot) | 425 |
Aantal pagina's | 1 |
Tijdschrift | Brain Stimulation |
Volume | 12 |
Nummer van het tijdschrift | 2 |
DOI's | |
Status | Published - 1 mrt 2019 |