Projecten per jaar
Samenvatting
Intermittent theta burst stimulation (iTBS) delivered to the dorsolateral prefrontal cortex (DLPFC) has been investigated as a promising treatment for stress and stress‐related mental disorders such as major depression, yet large individual differences in responsiveness demand further exploration and optimization of its effectiveness. Clinical research suggests that resting‐state functional connectivity (rsFC) between the DLPFC and the anterior cingulate cortex (ACC) can predict iTBS treatment response in depression. The present study aimed to investigate whether rsFC between the left DLPFC and ACC subregions could predict the degree to which the stress system is affected by iTBS. After assessment of baseline resting‐state fMRI data, 34 healthy female participants performed the Trier Social Stress Test on two separate days, each followed by active or sham iTBS over the left DLPFC. To evaluate iTBS effects on the stress‐system, salivary cortisol was measured throughout the procedure. Our results showed that a stronger negative correlation between the left DLPFC and the caudal ACC was linked to a larger attenuation of stress‐system sensitivity during active, but not during sham iTBS. In conclusion, based on individual rsFC between left DLPFC and caudal ACC, iTBS could be optimized to more effectively attenuate deregulation of the stress system.
Originele taal-2 | English |
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Pagina's (van-tot) | 5301-5312 |
Aantal pagina's | 12 |
Tijdschrift | Human Brain Mapping |
Volume | 41 |
Nummer van het tijdschrift | 18 |
Vroegere onlinedatum | 3 okt 2020 |
DOI's | |
Status | Published - 15 dec 2020 |
Bibliografische nota
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.Vingerafdruk
Duik in de onderzoeksthema's van 'Individual resting-state frontocingular functional connectivity predicts the intermittent theta burst stimulation response to stress in healthy female volunteers'. Samen vormen ze een unieke vingerafdruk.Projecten
- 1 Actief
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SRP57: SRP-Onderzoekszwaartepunt: The Social and Cognitive Brain
Deroost, N., Van Overwalle, F. & Deroost, N.
1/03/19 → 29/02/28
Project: Fundamenteel