Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy: Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy

Onderzoeksoutput: Scientific review

3 Citaten (Scopus)

Samenvatting

Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. Despite the arsenal of defense strategies against foreign invaders, myeloid cells succumb to the instructions of an established tumor. Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression.

Originele taal-2English
Artikelnummer1395
Pagina's (van-tot)1-14
Aantal pagina's14
TijdschriftFrontiers in Immunology
Volume11
Nummer van het tijdschrift1395
DOI's
StatusPublished - 9 jul 2020

Bibliografische nota

Copyright © 2020 Lebegge, Arnouk, Bardet, Kiss, Raes and Van Ginderachter.

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