Intensity-Based Deformable Registration: Introduction and Overview

The purpose of this chapter is to give an introduction to intensity-based deformable image registration and present a brief overview of the state-of-the-art. First, we lay out the basic principles of deformable registration. Next, the key components of the registration framework are discussed in detail and two popular algorithms for deformable registration are described as an example. We review past studies on respiratory motion estimation for radiotherapy. Finally, we briefly list useful open-source software packages and available image and validation data sets for deformable registration of the thorax.