TY - JOUR
T1 - International multicentre validation of the arteriovenous malformation-related intracerebral haemorrhage (AVICH) score
AU - Neidert, Marian C
AU - Lawton, Michael T
AU - Kim, Louis J
AU - Nerva, John D
AU - Kurisu, Kaoru
AU - Ikawa, Fusao
AU - Konczalla, Juergen
AU - Dinc, Nazife
AU - Seifert, Volker
AU - Habdank-Kolaczkowski, Julian
AU - Hatano, Taketo
AU - Hayase, Makoto
AU - Podlesek, Dino
AU - Schackert, Gabriele
AU - Wanet, Thomas
AU - Gläsker, Sven
AU - Griessenauer, Christoph J
AU - Ogilvy, Christopher S
AU - Kneist, Andreas
AU - Sure, Ulrich
AU - Seifert, Burkhardt
AU - Regli, Luca
AU - Bozinov, Oliver
AU - Burkhardt, Jan-Karl
N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2017/10/5
Y1 - 2017/10/5
N2 - OBJECTIVE: The recently published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better outcome prediction for patients with arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH scores. Here we present the results of a multicentre, external validation of the AVICH score.METHODS: All participating centres (n=11) provided anonymous data on 325 patients to form the Spetzler-Martin (SM) grade, the supplemented SM (sSM) grade, the ICH score and the AVICH score. Modified Rankin score (mRS) at last follow-up (mean 25.6 months) was dichotomized into favourable (mRS 0-2, n=210) and unfavourable (mRS 3-6;n=115). Univariate and AUROC analyses were performed to validate the AVICH score.RESULTS: Except nidus structure and AVM size, all single parameters forming the SM, sSM, ICH and AVICH score and the scores itself were significantly different between both outcome groups in the univariate analysis. The AVICH score was confirmed to be the highest predictive outcome score with an AUROC of 0.765 compared with 0.705 for the ICH score and 0.682 for the sSM grade.CONCLUSION: The multicentre-validated AVICH score predicts clinical outcome superior to pre-existing scores. We suggest the routine use of this score for future clinical outcome prediction and in clinical research.TRIAL REGISTRATION NUMBER: NCT02920645.
AB - OBJECTIVE: The recently published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better outcome prediction for patients with arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH scores. Here we present the results of a multicentre, external validation of the AVICH score.METHODS: All participating centres (n=11) provided anonymous data on 325 patients to form the Spetzler-Martin (SM) grade, the supplemented SM (sSM) grade, the ICH score and the AVICH score. Modified Rankin score (mRS) at last follow-up (mean 25.6 months) was dichotomized into favourable (mRS 0-2, n=210) and unfavourable (mRS 3-6;n=115). Univariate and AUROC analyses were performed to validate the AVICH score.RESULTS: Except nidus structure and AVM size, all single parameters forming the SM, sSM, ICH and AVICH score and the scores itself were significantly different between both outcome groups in the univariate analysis. The AVICH score was confirmed to be the highest predictive outcome score with an AUROC of 0.765 compared with 0.705 for the ICH score and 0.682 for the sSM grade.CONCLUSION: The multicentre-validated AVICH score predicts clinical outcome superior to pre-existing scores. We suggest the routine use of this score for future clinical outcome prediction and in clinical research.TRIAL REGISTRATION NUMBER: NCT02920645.
KW - cerebrovascular
UR - http://www.scopus.com/inward/record.url?scp=85049035612&partnerID=8YFLogxK
U2 - 10.1136/jnnp-2017-316259
DO - 10.1136/jnnp-2017-316259
M3 - Article
C2 - 28986471
VL - 89
SP - 1163
EP - 1166
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 11
ER -