Involvement of the somatostatin-2 receptor in the anticonvulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats.

Bart Stragier, Ralph Clinckers, Guy Ebinger, Yvette Michotte, Ilse Julia Smolders

Onderzoeksoutput: Meeting abstract (Book)Research

Samenvatting

The anti-convulsant properties of angiotensin IV (Ang IV), an inhibitor of insulin-regulated aminopeptidase (IRAP) and somatostatin-14, a substrate of IRAP, were evaluated in the acute pilocarpine rat seizure model. Simultaneously, the neurochemical changes in the hippocampus were monitored using in vivo microdialysis. Intracerebroventricularly (i.c.v.) administered Ang IV or somatostatin-14 caused a significant increase in the hippocampal extracellular dopamine and serotonin levels and protected rats against pilocarpine-induced seizures. These effects of Ang IV were both blocked by concomitant i.c.v. administration of the somatostatin receptor-2 antagonist cyanamid 154806. These results reveal a possible role for dopamine and serotonin in the anti-convulsant effect of Ang IV and somatostatin-14. Our study suggests that the ability of Ang IV to inhibit pilocarpine-induced convulsions is dependent on somatostatin receptor-2 activation, and is possibly mediated via the inhibition of IRAP resulting in an elevated concentration of somatostatin-14 in the brain.
Originele taal-2English
Titel11th Congress of the European Federation of Neurological Societies, Brussels, Belgium
StatusPublished - 2007
EvenementUnknown - Stockholm, Sweden
Duur: 21 sep 200925 sep 2009

Publicatie series

Naam11th Congress of the European Federation of Neurological Societies, Brussels, Belgium

Conference

ConferenceUnknown
Land/RegioSweden
StadStockholm
Periode21/09/0925/09/09

Vingerafdruk

Duik in de onderzoeksthema's van 'Involvement of the somatostatin-2 receptor in the anticonvulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats.'. Samen vormen ze een unieke vingerafdruk.

Citeer dit