Background: Dual energy X-ray absorptiometry (DXA) equipment is designed to provide information for animal and human research and clinical diagnosis. Its physical concepts are based on a molecular 3-compartment model of body composition. Objectives: To understand the physiological relation between DXA and functional body components at tissue system level (e.g. adipose tissue and muscle mass) two cross-validation studies were undertaken. Methods: The first study compared DXA fan beam scans with direct dissection and computed tomography (CT) scanning data at whole body level in a sample of 12 porcine carcasses. The second study related regional DXA variables with absolute tissue masses obtained by CT scanning in 11 humans. Results: Both studies show that DXA and functional body components are significantly interrelated (with r-values between 0.60 and 1.00, P<0.01). However significant systematic differences between the majority of variables both on whole body as well as regional level were found, except for ash weight (P =0.086) in animals and subcutaneous adipose tissue in humans (P = 0.773) respectively. Conclusions: The results of the cross-validation studies suggest that DXA and functional body components have different quantitative and physiological significance. The use of DXA in research and clinical diagnosis requires further clarification on its ability to assess tissue variability.
Originele taal-2English
Pagina's (van-tot)S10-S19
Aantal pagina's1
TijdschriftEuropean Journal of Clinical Nutrition
Nummer van het tijdschriftS1
StatusPublished - 2015
Evenement10th international symposium on in vivo body composition studies - Cascais, Portugal
Duur: 11 jun 201414 jun 2014


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