Samenvatting
AIM
To investigate the relationship of post-operative fatigue with muscle endurance and circulating inflammatory cytokines.
METHODS
Prospective study including 84 patients (41 female and 43 male, age 24-91 years) scheduled for elective abdominal surgery (42 open and 42 laparoscopic). All patients were assessed one day before and 2 days after surgery; and if still hospitalized at day 4 (N=78) and day 7 (N=50) post-surgery. Outcome measures were self-perceived fatigue (Profile of Mood State), Fatigue Resistance (FR, time during which grip strength drops to 50% of its maximum), Grip Work (GW, work output delivered by the muscles during the FR-test), VAS for Pain and circulating Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-alpha. Data were analyzed using ANOVA for Repeated Measures, and correlations for changes over time were computed between perceived fatigue and the other outcome parameters.
RESULTS
All outcome-parameters worsened significantly (p75), patients aged >75 years worsened significantly more and recovered significantly less rapidly for FR at day4 post-surgery compared to the younger patients (p
CONCLUSION
Post-operative fatigue is related to reduced muscle endurance and elevated IL-6. Elderly patients show a higher impact of surgery on muscle endurance.
To investigate the relationship of post-operative fatigue with muscle endurance and circulating inflammatory cytokines.
METHODS
Prospective study including 84 patients (41 female and 43 male, age 24-91 years) scheduled for elective abdominal surgery (42 open and 42 laparoscopic). All patients were assessed one day before and 2 days after surgery; and if still hospitalized at day 4 (N=78) and day 7 (N=50) post-surgery. Outcome measures were self-perceived fatigue (Profile of Mood State), Fatigue Resistance (FR, time during which grip strength drops to 50% of its maximum), Grip Work (GW, work output delivered by the muscles during the FR-test), VAS for Pain and circulating Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-alpha. Data were analyzed using ANOVA for Repeated Measures, and correlations for changes over time were computed between perceived fatigue and the other outcome parameters.
RESULTS
All outcome-parameters worsened significantly (p75), patients aged >75 years worsened significantly more and recovered significantly less rapidly for FR at day4 post-surgery compared to the younger patients (p
CONCLUSION
Post-operative fatigue is related to reduced muscle endurance and elevated IL-6. Elderly patients show a higher impact of surgery on muscle endurance.
| Originele taal-2 | English |
|---|---|
| Titel | 5th Congress of the European Union geriatric Medicine Society, 3-6 september 2008, Copenhagen, Denmark |
| Status | Published - sep 2008 |
| Evenement | Unknown - Stockholm, Sweden Duur: 21 sep 2009 → 25 sep 2009 |
Conference
| Conference | Unknown |
|---|---|
| Land/Regio | Sweden |
| Stad | Stockholm |
| Periode | 21/09/09 → 25/09/09 |